Tshz1 teashirt zinc finger family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tshz1provided by MGI
Official Full Name: teashirt zinc finger family member 1provided by MGI
Primary source: MGI:MGI:1346031
See related: Ensembl:ENSMUSG00000046982 AllianceGenome:MGI:1346031
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsh1; Mtsh1; NY-CO-33; Sdccag33; teashirt1; D18Bwg1409e; 5730407I04Rik
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within anterior/posterior pattern specification; middle ear morphogenesis; and soft palate development. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and limb. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 22.0), frontal lobe adult (RPKM 18.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 57.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (84029752..84105833, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (84011627..84087708, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
Title: A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.
Tshz1 is an essential transcription factor for the development and physiological function of phrenic and hypoglossal motor neurons.
Title: Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.
Identify E2F1 as the induction factor for the RA-dependent transcription of Tshz1.
Title: E2F1 Mediates the Retinoic Acid-Induced Transcription of Tshz1 during Neuronal Differentiation in a Cell Division-Dependent Manner.
the loss of intercalated cells in mouse Tshz1 mutants correlates well with defects in fear extinction as well as the appearance of depression-like and abnormal social interaction behaviors
Title: Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.
Adult Tshz1(+/-) mice display glucose intolerance due to defects in glucose-stimulated insulin secretion associated with reduced Pdx1 and Clec16a expression in Tshz1(+/-) islets.
Title: Tshz1 Regulates Pancreatic β-Cell Maturation.
role for mTsh genes in the establishment of regional identity and specification of cell types in the developing and adult forebrain
Title: Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.
In the craniofacial region, loss of Tshz1 function leads to specific malformations of middle ear components, including the malleus and the tympanic ring.
Title: Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
Title: Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102961 (e-PCR)
- UniSTS:97295

RH126143 (e-PCR)
- UniSTS:162855

5730407I04Rik (e-PCR), detects polymorphism
- UniSTS:142185

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within soft palate development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: teashirt homolog 1

Names: serologically defined colon cancer antigen 3 homolog; serologically defined colon cancer antigen 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081300.2 → NP_001074769.1 teashirt homolog 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC124012

Consensus CDS

CCDS37876.1

UniProtKB/Swiss-Prot

Q5DTH5, Q6PE60, Q8VD19, Q9JLD5

Related

ENSMUSP00000089388.6, ENSMUST00000060303.10

Conserved Domains (3) summary

cd00086
Location:892 → 960

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:248 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:976 → 1067

zf-C2H2_2; C2H2 type zinc-finger (2 copies)
NM_001364993.1 → NP_001351922.1 teashirt homolog 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC124012, CJ130710

Consensus CDS

CCDS89292.1

UniProtKB/TrEMBL

A0A494B920

Conserved Domains (2) summary

cd00086
Location:628 → 696

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:45 → 67

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001364994.1 → NP_001351923.1 teashirt homolog 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC124012

Consensus CDS

CCDS89292.1

UniProtKB/TrEMBL

A0A494B920

Related

ENSMUSP00000157454.2, ENSMUST00000175783.3

Conserved Domains (2) summary

cd00086
Location:628 → 696

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:45 → 67

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

84029752..84105833 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250275.1 → XP_030106135.1 teashirt homolog 1 isoform X1

UniProtKB/Swiss-Prot

Q5DTH5, Q6PE60, Q8VD19, Q9JLD5

Conserved Domains (3) summary

cd00086
Location:892 → 960

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:248 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:976 → 1067

zf-C2H2_2; C2H2 type zinc-finger (2 copies)
XM_030250273.1 → XP_030106133.1 teashirt homolog 1 isoform X1

UniProtKB/Swiss-Prot

Q5DTH5, Q6PE60, Q8VD19, Q9JLD5

Conserved Domains (3) summary

cd00086
Location:892 → 960

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:248 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:976 → 1067

zf-C2H2_2; C2H2 type zinc-finger (2 copies)
XM_030250274.2 → XP_030106134.1 teashirt homolog 1 isoform X1

UniProtKB/Swiss-Prot

Q5DTH5, Q6PE60, Q8VD19, Q9JLD5

Conserved Domains (3) summary

cd00086
Location:892 → 960

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:248 → 270

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12756
Location:976 → 1067

zf-C2H2_2; C2H2 type zinc-finger (2 copies)