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    TEX28 testis expressed 28 [ Homo sapiens (human) ]

    Gene ID: 1527, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TEX28provided by HGNC
    Official Full Name
    testis expressed 28provided by HGNC
    Primary source
    HGNC:HGNC:2563
    See related
    Ensembl:ENSG00000278057 MIM:300092; AllianceGenome:HGNC:2563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    fTEX; MRX99; CXorf2; TEX28P1; TEX28P2
    Summary
    Predicted to be located in membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis (RPKM 2.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See TEX28 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154271265..154295211, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152507099..152531726, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_003871103.3 (1705244..1729190, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TEX28 pseudogene 3 Neighboring gene opsin 1, medium wave sensitive 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153523339-153523840 Neighboring gene transketolase like 1 Neighboring gene uncharacterized LOC105373386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. Metlapally R, et al. Invest Ophthalmol Vis Sci, 2009 Apr. PMID 19098318, Free PMC Article
    2. An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays. Ueyama H, et al. J Hum Genet, 2004. PMID 15378397
    3. Identification of a gene within the tandem array of red and green color pigment genes. Hanna MC, et al. Genomics, 1997 Aug 1. PMID 9268643
    4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994, Free PMC Article
    5. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TEX28 gene CNVs (copy number variations) appear to be associated with the MYP1 X-linked myopia phenotypes.
      Title: Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies.
    2. proposed a structure of the second gene of 3-gene arrays, Green-pTEX-Green-pTEX-Green-fTEX and Red-pTEX-Red-pTEX-Red-fTEX, in color-vision-deficient subjects
      Title: An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific protein TEX28

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205201.2 → NP_001192130.1  testis-specific protein TEX28

      See identical proteins and their annotated locations for NP_001192130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC245140
      Consensus CDS
      CCDS14744.2
      UniProtKB/Swiss-Prot
      B1B1E8, D3DWW5, O15482
      Related
      ENSP00000478834.1, ENST00000619903.4
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 380
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_001586.3 → NP_001577.1  testis-specific protein TEX28

      See identical proteins and their annotated locations for NP_001577.1

      Status: VALIDATED

      Source sequence(s)
      AC245140
      Consensus CDS
      CCDS14744.2
      UniProtKB/Swiss-Prot
      B1B1E8, D3DWW5, O15482
      Related
      ENSP00000482010.1, ENST00000617225.5
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 380
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      154271265..154295211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531118.3 → XP_011529420.1  testis-specific protein TEX28 isoform X2

      See identical proteins and their annotated locations for XP_011529420.1

      Conserved Domains (1) summary
      pfam10267
      Location:51 → 383
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. XM_011531117.1 → XP_011529419.1  testis-specific protein TEX28 isoform X2

      See identical proteins and their annotated locations for XP_011529419.1

      Conserved Domains (1) summary
      pfam10267
      Location:51 → 383
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_011531116.1 → XP_011529418.1  testis-specific protein TEX28 isoform X1

      Conserved Domains (1) summary
      pfam10267
      Location:110 → 442
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152507099..152531726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15482.1 GenPept UniProtKB/Swiss-Prot:O15482

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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