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    Fos FBJ osteosarcoma oncogene [ Mus musculus (house mouse) ]

    Gene ID: 14281, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fosprovided by MGI
    Official Full Name
    FBJ osteosarcoma oncogeneprovided by MGI
    Primary source
    MGI:MGI:95574
    See related
    Ensembl:ENSMUSG00000021250 AllianceGenome:MGI:95574
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cFos; c-fos; D12Rfj1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including positive regulation of osteoclast differentiation; response to muscle stretch; and skeletal muscle cell differentiation. Located in endoplasmic reticulum and nucleus. Part of transcription factor AP-1 complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in duodenum adult (RPKM 93.1), small intestine adult (RPKM 77.3) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Fos in Genome Data Viewer
    Location:
    12 D2; 12 39.7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85520664..85524048)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85473890..85477274)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46370 Neighboring gene STARR-seq mESC enhancer starr_32776 Neighboring gene VISTA enhancer mm260 Neighboring gene predicted gene, 38543 Neighboring gene STARR-seq mESC enhancer starr_32778 Neighboring gene STARR-positive B cell enhancer ABC_E7163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86827838-86828025 Neighboring gene STARR-positive B cell enhancer mm9_chr12:86828722-86829022 Neighboring gene predicted gene, 32296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86912459-86912666 Neighboring gene predicted gene, 32348

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (10) 
    • Targeted (13)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables R-SMAD binding  
    enables R-SMAD binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables chromatin binding PubMed 
    enables double-stranded DNA binding  
    enables identical protein binding  
    enables identical protein binding  
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coregulator binding  
    enables transcription coregulator binding  
    Items 1 - 25 of 31
    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction  
    involved_in SMAD protein signal transduction  
    involved_in cellular response to cadmium ion  
    acts_upstream_of_or_within cellular response to calcium ion PubMed 
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to hypoxia  
    involved_in cellular response to parathyroid hormone stimulus  
    involved_in cellular response to phorbol 13-acetate 12-myristate  
    involved_in cellular response to prolactin  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to reactive oxygen species  
    acts_upstream_of_or_within cellular response to stimulus PubMed 
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to zinc ion starvation  
    involved_in cerebral cortex development  
    involved_in conditioned taste aversion  
    involved_in female pregnancy  
    involved_in medium-term memory  
    involved_in mononuclear cell differentiation  
    involved_in myoblast proliferation  
    acts_upstream_of_or_within nervous system development PubMed 
    involved_in neural retina development  
    involved_in neuron differentiation  
    acts_upstream_of osteoclast differentiation PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    acts_upstream_of_or_within positive regulation of osteoclast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to activity  
    involved_in response to cAMP  
    involved_in response to corticosterone  
    involved_in response to ethanol  
    involved_in response to gravity  
    involved_in response to immobilization stress  
    involved_in response to insulin  
    involved_in response to light stimulus  
    involved_in response to lipopolysaccharide  
    acts_upstream_of_or_within response to muscle stretch PubMed 
    involved_in response to progesterone  
    involved_in response to toxic substance  
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation PubMed 
    involved_in skeletal muscle cell proliferation  
    acts_upstream_of transcription by RNA polymerase II PubMed 
    involved_in transcription by RNA polymerase II  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 56
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of protein-DNA complex  
    part_of protein-DNA complex  
    part_of transcription factor AP-1 complex PubMed 
    part_of transcription factor AP-1 complex  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    protein c-Fos
    Names
    cellular oncogene fos
    proto-oncogene c-Fos
    proto-oncogene protein c-fos
    transcription factor AP-1 subunit c-Fos

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010234.3NP_034364.1  protein c-Fos

      See identical proteins and their annotated locations for NP_034364.1

      Status: VALIDATED

      Source sequence(s)
      AC159244
      Consensus CDS
      CCDS26059.1
      UniProtKB/Swiss-Prot
      P01101
      UniProtKB/TrEMBL
      Q3U463
      Related
      ENSMUSP00000021674.7, ENSMUST00000021674.7
      Conserved Domains (1) summary
      cd14721
      Location:147200
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85520664..85524048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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