RNF141 ring finger protein 141 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF141provided by HGNC
Official Full Name: ring finger protein 141provided by HGNC
Primary source: HGNC:HGNC:21159
See related: Ensembl:ENSG00000110315 MIM:616641; AllianceGenome:HGNC:21159
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZFP26; RFP141; ZNF230
Summary: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 30.2), esophagus (RPKM 28.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4; 11p15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (10511673..10541187, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (10596148..10625698, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (10533220..10562734, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A germ cell-specific transcription factor RFP141 reveals a unique RING fold.
Title: The zinc finger domain of RING finger protein 141 reveals a unique RING fold.
Analysis of the mouse counterpart.
Title: Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91769 (e-PCR)
- UniSTS:90632

D11S954E (e-PCR)
- UniSTS:147469

STS-N35020 (e-PCR)
- UniSTS:82194

D10S275 (e-PCR)
- UniSTS:147992

D11S2260E (e-PCR)
- UniSTS:58434

A002V33 (e-PCR)
- UniSTS:13652

RH46097 (e-PCR)
- UniSTS:41575

D11S2321E (e-PCR)
- UniSTS:151419

RH36905 (e-PCR)
- UniSTS:87932

D11S4386 (e-PCR)
- UniSTS:25227

D11S2258E (e-PCR)
- UniSTS:79758

RNF141_1785 (e-PCR)
- UniSTS:277681

RH36087 (e-PCR)
- UniSTS:2027

STS-N34870 (e-PCR)
- UniSTS:19692

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING finger protein 141

Names: C3HC4-like zinc finger protein; zinc finger protein 230

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.