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    STK11 serine/threonine kinase 11 [ Homo sapiens (human) ]

    Gene ID: 6794, updated on 10-Dec-2024

    Summary

    Official Symbol
    STK11provided by HGNC
    Official Full Name
    serine/threonine kinase 11provided by HGNC
    Primary source
    HGNC:HGNC:11389
    See related
    Ensembl:ENSG00000118046 MIM:602216; AllianceGenome:HGNC:11389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PJS; LKB1; hLKB1
    Summary
    The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]
    Expression
    Broad expression in testis (RPKM 28.3), spleen (RPKM 10.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STK11 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1205778..1228431)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1174325..1196989)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1205777..1228430)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene strawberry notch homolog 2 Neighboring gene collagen alpha-1(VII) chain Neighboring gene SBNO2 intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13590 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:1177383-1178582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1179969-1180484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1184302-1184862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1184863-1185421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9667 Neighboring gene Sharpr-MPRA regulatory region 12578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13593 Neighboring gene Sharpr-MPRA regulatory region 734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9670 Neighboring gene Sharpr-MPRA regulatory region 13808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1208870-1209555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1210982-1211768 Neighboring gene high mobility group box 2 pseudogene 1 Neighboring gene serine/threonine kinase 11 intron 1 Alu-mediated recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13596 Neighboring gene Sharpr-MPRA regulatory region 9448 Neighboring gene serine/threonine kinase 11 intron 3 Alu-mediated recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1239955-1240513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13599 Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13600 Neighboring gene CBARP divergent transcript Neighboring gene ATP synthase F1 subunit delta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (171 hits/1348 screens)

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in STK11 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Carcinoma of pancreas
    MedGen: C0235974 GeneReviews: Not available
    Compare labs
    Germ cell tumor of testis
    MedGen: C1336708 OMIM: 273300 GeneReviews: Not available
    Compare labs
    Melanoma, cutaneous malignant, susceptibility to, 1
    MedGen: C1835047 OMIM: 155600 GeneReviews: Not available
    Compare labs
    Peutz-Jeghers syndrome
    MedGen: C0031269 OMIM: 175200 GeneReviews: Peutz-Jeghers Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2021-11-10)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study of Alzheimer's disease with psychotic symptoms.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables DNA-dependent protein kinase activity  
    enables LRR domain binding  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables p53 binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activator activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 31
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response PubMed 
    acts_upstream_of_negative_effect G1 to G0 transition PubMed 
    acts_upstream_of_negative_effect G1 to G0 transition PubMed 
    involved_in Golgi localization  
    involved_in T cell receptor signaling pathway  
    acts_upstream_of_or_within activation of protein kinase activity PubMed 
    involved_in activation of protein kinase activity PubMed 
    involved_in anoikis PubMed 
    involved_in autophagy  
    involved_in axonogenesis  
    involved_in cellular response to UV-B PubMed 
    involved_in chromatin remodeling  
    involved_in dendrite extension  
    involved_in epithelial cell proliferation involved in prostate gland development  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity PubMed 
    involved_in establishment of cell polarity  
    involved_in glucose homeostasis  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of epithelial cell proliferation involved in prostate gland development  
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of axonogenesis  
    involved_in positive regulation of gluconeogenesis  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in positive regulation of vesicle transport along microtubule  
    involved_in positive regulation of vesicle transport along microtubule PubMed 
    involved_in positive thymic T cell selection  
    involved_in protein autophosphorylation PubMed 
    involved_in protein dephosphorylation PubMed 
    involved_in protein localization to nucleus  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of Wnt signaling pathway  
    involved_in regulation of cell cycle  
    involved_in regulation of cell growth  
    involved_in regulation of dendrite morphogenesis  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in regulation of signal transduction by p53 class mediator  
    involved_in response to activity  
    involved_in response to glucagon  
    involved_in response to ionizing radiation  
    involved_in response to lipid  
    involved_in response to thyroid hormone  
    involved_in signal transduction  
    involved_in spermatogenesis  
    involved_in tissue homeostasis  
    involved_in vasculature development  
    Items 1 - 25 of 54
    Component Evidence Code Pubs
    located_in Z disc  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular exosome PubMed 
    part_of intracellular protein-containing complex PubMed 
    located_in membrane  
    located_in mitochondrion PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    part_of serine/threonine protein kinase complex PubMed 
    part_of serine/threonine protein kinase complex  

    General protein information

    Preferred Names
    serine/threonine-protein kinase STK11
    Names
    liver kinase B1
    polarization-related protein LKB1
    renal carcinoma antigen NY-REN-19
    serine/threonine-protein kinase 11
    serine/threonine-protein kinase LKB1
    NP_000446.1
    NP_001394184.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007460.2 RefSeqGene

      Range
      21393..44029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_319

    mRNA and Protein(s)

    1. NM_000455.5NP_000446.1  serine/threonine-protein kinase STK11 isoform 1

      See identical proteins and their annotated locations for NP_000446.1

      Status: REVIEWED

      Source sequence(s)
      AC011544, BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451
      Consensus CDS
      CCDS45896.1
      UniProtKB/Swiss-Prot
      B2RBX7, E7EW76, Q15831
      UniProtKB/TrEMBL
      A0A0S2Z4D1, A6YR18
      Related
      ENSP00000324856.6, ENST00000326873.12
      Conserved Domains (1) summary
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
    2. NM_001407255.1NP_001394184.1  serine/threonine-protein kinase STK11 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011544
      UniProtKB/TrEMBL
      Q9HBS3
      Related
      ENSP00000498804.1, ENST00000652231.1

    RNA

    1. NR_176325.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004221, AC011544
      Related
      ENST00000714323.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1205778..1228431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1174325..1196989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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