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    ZNF783 zinc finger protein 783 [ Homo sapiens (human) ]

    Gene ID: 100289678, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF783provided by HGNC
    Official Full Name
    zinc finger protein 783provided by HGNC
    Primary source
    HGNC:HGNC:27222
    See related
    Ensembl:ENSG00000204946 AllianceGenome:HGNC:27222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 4.3), lymph node (RPKM 3.9) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF783 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149262196..149284994)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150444011..150466766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148959287..148982085)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene zinc finger protein 282 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148978524-148979060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18754 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148982524-148982701 Neighboring gene AI894139 pseudogene Neighboring gene tRNA-Cys (anticodon GCA) 1-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Gauci S, et al. Anal Chem, 2009 Jun 1. PMID 19413330
    2. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    3. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. Kang H, et al. Neurobiol Dis, 2015 Jan. PMID 25315684
    4. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
    5. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12914, FLJ16713, DKFZp762P2111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 783
    Names
    protein ZNF783
    zinc finger family member 783

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195220.2 → NP_001182149.1  zinc finger protein 783

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC004890
      Consensus CDS
      CCDS56519.1
      UniProtKB/Swiss-Prot
      C9J9J2, Q6ZMS7
      Related
      ENSP00000410890.1, ENST00000434415.6
      Conserved Domains (8) summary
      cd07765
      Location:143 → 182
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:143 → 202
      KRAB; krueppel associated box
      COG5048
      Location:468 → 516
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:468 → 488
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:57 → 112
      DUF3669; Zinc finger protein
      pfam13465
      Location:480 → 505
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_144366.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004890

    2. NR_144367.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004890

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149262196..149284994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419692.1 → XP_047275648.1  zinc finger protein 783 isoform X2

    2. XM_011515701.3 → XP_011514003.1  zinc finger protein 783 isoform X1

      Conserved Domains (8) summary
      cd07765
      Location:154 → 193
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:154 → 213
      KRAB; krueppel associated box
      COG5048
      Location:479 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:449 → 469
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:479 → 499
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:68 → 123
      DUF3669; Zinc finger protein
      pfam13465
      Location:491 → 516
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_001744503.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150444011..150466766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356965.1 → XP_054212940.1  zinc finger protein 783 isoform X2

    2. XM_054356964.1 → XP_054212939.1  zinc finger protein 783 isoform X1

    RNA

    1. XR_008487516.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMS7.2 GenPept UniProtKB/Swiss-Prot:Q6ZMS7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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