ICOSLG inducible T cell costimulator ligand [Homo sapiens (human)] - Gene

Summary

Official Symbol: ICOSLGprovided by HGNC
Official Full Name: inducible T cell costimulator ligandprovided by HGNC
Primary source: HGNC:HGNC:17087
See related: Ensembl:ENSG00000160223 MIM:605717; AllianceGenome:HGNC:17087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; IMD119
Summary: Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q22.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (44216981..44240943, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (42571002..42595008, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (45642874..45660826, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ICOS-ICOSL pathway enhances NKT-like cell antiviral function in pregnant women with COVID-19.
Title: ICOS-ICOSL pathway enhances NKT-like cell antiviral function in pregnant women with COVID-19.
Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma.
Title: Epstein-Barr virus-encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma.
ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells.
Title: ICOSLG acts as an oncogene to promote glycolysis, proliferation, migration, and invasion in gastric cancer cells.
Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Title: Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
Title: Expression and prognosis of inducible T-cell co-stimulator and its ligand in Chinese stage I-III lung adenocarcinoma patients.
Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
Title: Mesenchymal stem cells regulate type 2 innate lymphoid cells via regulatory T cells through ICOS-ICOSL interaction.
Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-alpha-B7-H2-dependent pathway in human gastric cancer.
Title: Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-α-B7-H2-dependent pathway in human gastric cancer.
Dysregulated NF-kappaB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
Title: Dysregulated NF-κB-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
[High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
Title: [High expression of ICOS on CD4(+) T cells and ICOSL on CD19(+) B cells in peripheral blood and its positive correlation with TRAb in Graves' disease].
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.
Title: Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 119 MedGen: C5935621 OMIM: 620825 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-52125 (e-PCR)
- UniSTS:67625

RH12408 (e-PCR)
- UniSTS:68192

SHGC-87685 (e-PCR)
- UniSTS:68756

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
involved_in T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T follicular helper cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in defense response	NAS Non-traceable Author Statement more info	PubMed
involved_in hyperosmotic response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of activated T cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ICOS ligand

Names: B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001283050.2 → NP_001269979.1 ICOS ligand isoform b precursor

See identical proteins and their annotated locations for NP_001269979.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.

Source sequence(s)

AA781960, AF199028, DC365972

Consensus CDS

CCDS63379.1

UniProtKB/TrEMBL

A0A8V8TQ42

Related

ENSP00000339477.4, ENST00000344330.9

Conserved Domains (2) summary

pfam07686
Location:20 → 131

V-set; Immunoglobulin V-set domain

cl11960
Location:153 → 225

Ig; Immunoglobulin domain
NM_001283051.2 → NP_001269980.1 ICOS ligand isoform c precursor

See identical proteins and their annotated locations for NP_001269980.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

AK090492, AP001058, BQ005303

Consensus CDS

CCDS63377.1

UniProtKB/Swiss-Prot

O75144

Related

ENSP00000383228.3, ENST00000400377.4

Conserved Domains (1) summary

cl11960
Location:36 → 108

Ig; Immunoglobulin domain
NM_001283052.2 → NP_001269981.1 ICOS ligand isoform d

See identical proteins and their annotated locations for NP_001269981.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AK294031, AP001058, BQ005303

Consensus CDS

CCDS93102.1

UniProtKB/TrEMBL

B7Z1W8, B7ZA28, B7ZA61

Related

ENSP00000514960.1, ENST00000700358.1

Conserved Domains (1) summary

cl11960
Location:68 → 140

Ig; Immunoglobulin domain
NM_001365759.2 → NP_001352688.1 ICOS ligand isoform e

Status: VALIDATED

Source sequence(s)

AP001058, AP001059

UniProtKB/TrEMBL

A0A8V8TQ42

Conserved Domains (1) summary

cl11960
Location:2 → 104

Ig; Immunoglobulin domain
NM_001395918.1 → NP_001382847.1 ICOS ligand isoform f precursor

Status: VALIDATED

Source sequence(s)

AP001058, AP001059

Consensus CDS

CCDS93104.1

UniProtKB/TrEMBL

A0A8V8TQ42, A0A8V8TQV9

Related

ENSP00000514957.1, ENST00000700355.1

Conserved Domains (3) summary

cd00096
Location:154 → 162

Ig; Ig strand B [structural motif]

cd20935
Location:23 → 135

IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)

cl11960
Location:149 → 224

Ig; Immunoglobulin domain
NM_015259.6 → NP_056074.1 ICOS ligand isoform a precursor

See identical proteins and their annotated locations for NP_056074.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.

Source sequence(s)

AK314369, AP001058, BQ005303

Consensus CDS

CCDS42952.1

UniProtKB/Swiss-Prot

A8MUZ1, O75144, Q9HD18, Q9NRQ1

UniProtKB/TrEMBL

A0A8V8TQ42, A0N0L8

Related

ENSP00000384432.3, ENST00000407780.8

Conserved Domains (2) summary

pfam07686
Location:20 → 131

V-set; Immunoglobulin V-set domain

cl11960
Location:153 → 212

Ig; Immunoglobulin domain