Replication interactions
Interaction |
Pubs |
Knockdown of purine-rich element binding protein A (PURA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Rev
|
rev
|
The interaction of Puralpha with HIV-1 RRE RNA occurs in the cytoplasm and enhances the association of HIV-1 Rev with the RRE |
PubMed
|
|
rev
|
HIV-1 Rev and PURA colocalize in the perinuclear compartment. The 18-50 amino-acid residues of Rev interact with the region of amino acids 73-123 in PURA |
PubMed
|
Tat
|
tat
|
HIV-1 Tat proteins from different clades modulate differently Pur-alpha and SMAD4 to bind the JCV non-coding control region and affect differently on SMAD4 localization to the nucleus |
PubMed
|
|
tat
|
Puralpha interacts with HIV-1 Tat to regulate the effect of Tat transactivating the HIV-1 LTR promoter, as well as the JCV promoter and other cellular promoters |
PubMed
|
|
tat
|
Puralpha self-associates in an RNA dependent manner, an effect that is inhibited by HIV-1 Tat |
PubMed
|
|
tat
|
Puralpha-mediated inhibition of protein translation can be inhibited by HIV-1 Tat |
PubMed
|
|
tat
|
HIV-1 Tat cooperates with Puralpha, cyclin T1, and CDK9 to activate the TNFalpha promoter and upregulate TNFalpha expression |
PubMed
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|
tat
|
Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter |
PubMed
|
|
tat
|
Binding of HIV-1 Tat to Puralpha is mediated through amino acids 49-72 of Tat and 100-121 of Puralpha, and is enhanced by RNA |
PubMed
|
|
tat
|
HIV-1 Tat downregulates the expression of p35, a neuron-specific activator of cdk5, and also binds to Puralpha, which associates with cdk5, leading to deregulation of neuronal differentiation and survival |
PubMed
|
Go to the HIV-1, Human Interaction Database