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    Morc2a microrchidia 2A [ Mus musculus (house mouse) ]

    Gene ID: 74522, updated on 9-Dec-2024

    Summary

    Official Symbol
    Morc2aprovided by MGI
    Official Full Name
    microrchidia 2Aprovided by MGI
    Primary source
    MGI:MGI:1921772
    See related
    Ensembl:ENSMUSG00000034543 AllianceGenome:MGI:1921772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zcwcc1; 8430403M08Rik
    Summary
    Enables histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 13.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Morc2a in Genome Data Viewer
    Location:
    11 A1; 11 2.56 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3599132..3640477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3649189..3690477)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11951 Neighboring gene STARR-positive B cell enhancer ABC_E6944 Neighboring gene STARR-seq mESC enhancer starr_28362 Neighboring gene taurine upregulated gene 1 Neighboring gene STARR-seq mESC enhancer starr_28363 Neighboring gene nucleolar and spindle associated protein 1 pseudogene Neighboring gene oxysterol binding protein 2 Neighboring gene predicted gene, 51881

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in constitutive heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing by heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ATPase MORC2A
    Names
    MORC family CW-type zinc finger protein 2A
    zinc finger CW-type coiled-coil domain protein 1
    zinc finger, CW-type with coiled-coil domain 1
    NP_001152760.1
    NP_001350131.1
    NP_937805.1
    XP_006514934.1
    XP_011242077.1
    XP_036012945.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159288.2NP_001152760.1  ATPase MORC2A isoform 1

      See identical proteins and their annotated locations for NP_001152760.1

      Status: VALIDATED

      Source sequence(s)
      AK173042, AL691413
      Consensus CDS
      CCDS48741.1
      UniProtKB/Swiss-Prot
      Q5QNQ7, Q69ZX6, Q6P547
      Related
      ENSMUSP00000091087.3, ENSMUST00000093389.9
      Conserved Domains (3) summary
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29169
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      cl26464
      Location:624741
      Atrophin-1; Atrophin-1 family
    2. NM_001363202.1NP_001350131.1  ATPase MORC2A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL691413
      Consensus CDS
      CCDS48741.1
      UniProtKB/Swiss-Prot
      Q5QNQ7, Q69ZX6, Q6P547
      Related
      ENSMUSP00000094176.4, ENSMUST00000096441.5
      Conserved Domains (3) summary
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29169
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
      cl26464
      Location:624741
      Atrophin-1; Atrophin-1 family
    3. NM_198162.2NP_937805.1  ATPase MORC2A isoform 2

      See identical proteins and their annotated locations for NP_937805.1

      Status: VALIDATED

      Source sequence(s)
      AL691413, BC059243
      UniProtKB/TrEMBL
      Q6PCN6
      Conserved Domains (4) summary
      PHA03247
      Location:562679
      PHA03247; large tegument protein UL36; Provisional
      pfam07496
      Location:433480
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:177389
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:173
      HATPase; Histidine kinase-like ATPase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3599132..3640477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243775.4XP_011242077.1  ATPase MORC2A isoform X1

      See identical proteins and their annotated locations for XP_011242077.1

      Conserved Domains (4) summary
      PHA03247
      Location:624741
      PHA03247; large tegument protein UL36; Provisional
      cd16931
      Location:18135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:239451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    2. XM_006514871.4XP_006514934.1  ATPase MORC2A isoform X1

      See identical proteins and their annotated locations for XP_006514934.1

      Conserved Domains (4) summary
      PHA03247
      Location:624741
      PHA03247; large tegument protein UL36; Provisional
      cd16931
      Location:18135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:239451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    3. XM_036157052.1XP_036012945.1  ATPase MORC2A isoform X2

      UniProtKB/TrEMBL
      Q6PCN6
      Conserved Domains (4) summary
      PHA03247
      Location:562679
      PHA03247; large tegument protein UL36; Provisional
      pfam07496
      Location:433480
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:177389
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:173
      HATPase; Histidine kinase-like ATPase domain