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    Gal3st1 galactose-3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 53897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gal3st1provided by MGI
    Official Full Name
    galactose-3-O-sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1858277
    See related
    Ensembl:ENSMUSG00000049721 AllianceGenome:MGI:1858277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cst; Gcst
    Summary
    Enables galactosylceramide sulfotransferase activity. Involved in galactosylceramide metabolic process. Acts upstream of or within galactosylceramide biosynthetic process; myelination; and spermatogenesis. Predicted to be located in membrane. Is expressed in brain; future spinal cord; heart ventricle; and spinal cord cervical region. Orthologous to human GAL3ST1 (galactose-3-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 105.3), duodenum adult (RPKM 57.3) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gal3st1 in Genome Data Viewer
    Location:
    11 A1; 11 2.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3933636..3949328)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3983636..3999328)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in galactosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within galactosylceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in galactosylceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within glycolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    galactosylceramide sulfotransferase
    Names
    3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase
    3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase
    Galcer sulfotransferase
    cerebroside sulfotransferase
    NP_001171162.1
    NP_001171174.1
    NP_001369219.1
    NP_001369220.1
    NP_058618.2
    XP_006514819.2
    XP_006514820.1
    XP_036012743.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177691.1NP_001171162.1  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_001171162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as form E) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK002510, AK007645, AL807395, BB804195
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000105608.2, ENSMUST00000109981.2
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family
    2. NM_001177703.1NP_001171174.1  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_001171174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK007645, AL807395, BB804195, CX239940
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000077815.2, ENSMUST00000078757.8
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family
    3. NM_001382290.1NP_001369219.1  galactosylceramide sulfotransferase

      Status: VALIDATED

      Source sequence(s)
      AL807395
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family
    4. NM_001382291.1NP_001369220.1  galactosylceramide sulfotransferase

      Status: VALIDATED

      Source sequence(s)
      AL807395
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family
    5. NM_016922.3NP_058618.2  galactosylceramide sulfotransferase

      See identical proteins and their annotated locations for NP_058618.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as form A) represents the longest transcript. Variants 1, 2 and 3 encode the same protein. An in-frame AUG is located 29 codons upstream of the annotated translation start site but is not being annotated as a start site since it would be inhibited by an overlapping uORF with a strong Kozak sequence.
      Source sequence(s)
      AK007645, AL807395, BB804195, CX239940
      Consensus CDS
      CCDS24373.1
      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Related
      ENSMUSP00000058348.8, ENSMUST00000063004.14
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3933636..3949328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156850.1XP_036012743.1  galactosylceramide sulfotransferase isoform X2

      Conserved Domains (1) summary
      cl22970
      Location:28437
      Sulfotransfer_2; Sulfotransferase family
    2. XM_006514757.5XP_006514820.1  galactosylceramide sulfotransferase isoform X1

      See identical proteins and their annotated locations for XP_006514820.1

      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family
    3. XM_006514756.5XP_006514819.2  galactosylceramide sulfotransferase isoform X1

      See identical proteins and their annotated locations for XP_006514819.2

      UniProtKB/Swiss-Prot
      Q9D8V6, Q9JHE4
      Conserved Domains (1) summary
      cl22970
      Location:4408
      Sulfotransfer_2; Sulfotransferase family