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    Sstr2 somatostatin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 20606, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sstr2provided by MGI
    Official Full Name
    somatostatin receptor 2provided by MGI
    Primary source
    MGI:MGI:98328
    See related
    Ensembl:ENSMUSG00000047904 AllianceGenome:MGI:98328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2
    Summary
    The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sstr2 in Genome Data Viewer
    Location:
    11 E2; 11 79.05 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113510153..113516854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113619327..113626028)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene predicted gene, 42094 Neighboring gene STARR-seq mESC enhancer starr_31085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables somatostatin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables somatostatin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables somatostatin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables somatostatin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peristalsis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatostatin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    somatostatin receptor type 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042606.3NP_001036071.1  somatostatin receptor type 2 isoform A

      See identical proteins and their annotated locations for NP_001036071.1

      Status: VALIDATED

      Source sequence(s)
      AL603705
      Consensus CDS
      CCDS59571.1
      UniProtKB/Swiss-Prot
      P30875, P30934, Q91Y73
      Related
      ENSMUSP00000138101.2, ENSMUST00000146390.3
      Conserved Domains (1) summary
      cd15971
      Location:44323
      7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_009217.5NP_033243.2  somatostatin receptor type 2 isoform B

      See identical proteins and their annotated locations for NP_033243.2

      Status: VALIDATED

      Source sequence(s)
      AL603705
      Consensus CDS
      CCDS25598.1
      UniProtKB/Swiss-Prot
      P30875
      Related
      ENSMUSP00000102241.2, ENSMUST00000106630.2
      Conserved Domains (1) summary
      cd15971
      Location:44323
      7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      113510153..113516854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)