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    Mzt1 mitotic spindle organizing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76789, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mzt1provided by MGI
    Official Full Name
    mitotic spindle organizing protein 1provided by MGI
    Primary source
    MGI:MGI:1924039
    See related
    Ensembl:ENSMUSG00000033186 AllianceGenome:MGI:1924039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mozart1; 2410129H14Rik
    Summary
    Predicted to be involved in gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; and mitotic spindle assembly. Predicted to be located in cytoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome; interphase microtubule organizing center; and spindle. Is expressed in several structures, including central nervous system; primary oocyte; and retina. Orthologous to human MZT1 (mitotic spindle organizing protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mzt1 in Genome Data Viewer
    Location:
    14 E2.2; 14 49.22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99271980..99283898, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99034544..99046453, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41228 Neighboring gene predicted gene, 18148 Neighboring gene STARR-seq mESC enhancer starr_37423 Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene Kruppel-like transcription factor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in gamma-tubulin complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-tubulin complex localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule nucleation by interphase microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-tubulin ring complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of gamma-tubulin ring complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in interphase microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitotic-spindle organizing protein 1
    Names
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175245.4NP_780454.1  mitotic-spindle organizing protein 1

      See identical proteins and their annotated locations for NP_780454.1

      Status: VALIDATED

      Source sequence(s)
      AK151232, AK169036, BB844588
      Consensus CDS
      CCDS49554.1
      UniProtKB/Swiss-Prot
      Q8BUR9
      Related
      ENSMUSP00000037557.9, ENSMUST00000042662.10
      Conserved Domains (1) summary
      pfam12554
      Location:1964
      MOZART1; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      99271980..99283898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248094.2XP_030103954.1  mitotic-spindle organizing protein 1 isoform X1