U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tbc1d4 TBC1 domain family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 210789, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tbc1d4provided by MGI
    Official Full Name
    TBC1 domain family, member 4provided by MGI
    Primary source
    MGI:MGI:2429660
    See related
    Ensembl:ENSMUSG00000033083 AllianceGenome:MGI:2429660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    As160; A930035N22; 5930406J04Rik
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within cellular response to insulin stimulus. Predicted to be located in vesicle. Predicted to be active in Golgi apparatus and cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D4 (TBC1 domain family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 6.6), adrenal adult (RPKM 6.0) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tbc1d4 in Genome Data Viewer
    Location:
    14 E2.3; 14 50.9 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (101679800..101846717, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (101442360..101609281, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37473 Neighboring gene predicted gene, 34361 Neighboring gene STARR-seq mESC enhancer starr_37474 Neighboring gene heat shock protein 1 (chaperonin), pseudogene 5 Neighboring gene predicted gene, 34417 Neighboring gene STARR-seq mESC enhancer starr_37476 Neighboring gene STARR-positive B cell enhancer ABC_E7344 Neighboring gene STARR-positive B cell enhancer ABC_E8574 Neighboring gene STARR-seq mESC enhancer starr_37480 Neighboring gene STARR-positive B cell enhancer ABC_E2432 Neighboring gene COMM domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_37481 Neighboring gene ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to insulin stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 4
    Names
    akt substrate of 160 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081278.3NP_001074747.2  TBC1 domain family member 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025630, CT573019, CT573033
      Consensus CDS
      CCDS49556.1
      UniProtKB/TrEMBL
      E9Q6Q8
      Related
      ENSMUSP00000125509.2, ENSMUST00000161991.8
      Conserved Domains (5) summary
      smart00164
      Location:8631077
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:751809
      DUF3350; Domain of unknown function (DUF3350)
      pfam13094
      Location:11371215
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    2. NM_001404671.1NP_001391600.1  TBC1 domain family member 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025630, CT573019, CT573033
    3. NM_001404672.1NP_001391601.1  TBC1 domain family member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025630, CT573019, CT573033
    4. NM_001404673.1NP_001391602.1  TBC1 domain family member 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025630, CT573019, CT573033
    5. NM_001404674.1NP_001391603.1  TBC1 domain family member 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT573019, CT573033
      UniProtKB/TrEMBL
      F6SUV7
      Related
      ENSMUSP00000124511.2, ENSMUST00000159951.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      101679800..101846717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518763.4XP_006518826.1  TBC1 domain family member 4 isoform X7

      Conserved Domains (5) summary
      smart00164
      Location:8641078
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      PTZ00440
      Location:10781209
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:751809
      DUF3350; Domain of unknown function (DUF3350)
    2. XM_017315935.2XP_017171424.1  TBC1 domain family member 4 isoform X5

      Conserved Domains (5) summary
      smart00164
      Location:8721086
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      PTZ00440
      Location:10861217
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:759817
      DUF3350; Domain of unknown function (DUF3350)
    3. XM_006518761.4XP_006518824.1  TBC1 domain family member 4 isoform X3

      Conserved Domains (5) summary
      smart00164
      Location:9191133
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      PTZ00440
      Location:11331264
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:806864
      DUF3350; Domain of unknown function (DUF3350)
    4. XM_006518760.4XP_006518823.1  TBC1 domain family member 4 isoform X2

      UniProtKB/TrEMBL
      E0CX53
      Related
      ENSMUSP00000124909.2, ENSMUST00000162617.8
      Conserved Domains (5) summary
      smart00164
      Location:9261140
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      PTZ00440
      Location:11401271
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:814872
      DUF3350; Domain of unknown function (DUF3350)
    5. XM_006518759.4XP_006518822.1  TBC1 domain family member 4 isoform X1

      See identical proteins and their annotated locations for XP_006518822.1

      UniProtKB/Swiss-Prot
      Q149C0, Q149C1, Q3T9E8, Q3TAQ5, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2, Q8BYJ6
      Conserved Domains (5) summary
      smart00164
      Location:9271141
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      PTZ00440
      Location:11411272
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:814872
      DUF3350; Domain of unknown function (DUF3350)
    6. XM_017315937.3XP_017171426.1  TBC1 domain family member 4 isoform X9

      UniProtKB/TrEMBL
      F6SUV7
      Conserved Domains (4) summary
      smart00164
      Location:772986
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PTZ00440
      Location:9861117
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:38289
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:659717
      DUF3350; Domain of unknown function (DUF3350)
    7. XM_030247707.2XP_030103567.1  TBC1 domain family member 4 isoform X10

      UniProtKB/TrEMBL
      F6SUV7
      Conserved Domains (4) summary
      smart00164
      Location:709923
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PTZ00440
      Location:9231054
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      cd01269
      Location:38289
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:596654
      DUF3350; Domain of unknown function (DUF3350)
    8. XM_006518767.2XP_006518830.1  TBC1 domain family member 4 isoform X13

      Conserved Domains (3) summary
      smart00164
      Location:245459
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PTZ00440
      Location:459590
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
      pfam11830
      Location:132190
      DUF3350; Domain of unknown function (DUF3350)
    9. XM_017315938.1XP_017171427.1  TBC1 domain family member 4 isoform X14

      Related
      ENSMUST00000161304.2
      Conserved Domains (2) summary
      smart00164
      Location:11225
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PTZ00440
      Location:225356
      PTZ00440; reticulocyte binding protein 2-like protein; Provisional
    10. XM_006518764.5XP_006518827.1  TBC1 domain family member 4 isoform X8

      Conserved Domains (4) summary
      smart00164
      Location:9271141
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:814872
      DUF3350; Domain of unknown function (DUF3350)
    11. XM_011245002.3XP_011243304.1  TBC1 domain family member 4 isoform X11

      See identical proteins and their annotated locations for XP_011243304.1

      UniProtKB/TrEMBL
      H7BX82
      Related
      ENSMUSP00000097913.4, ENSMUST00000100340.4
      Conserved Domains (3) summary
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:751809
      DUF3350; Domain of unknown function (DUF3350)
    12. XM_006518766.5XP_006518829.1  TBC1 domain family member 4 isoform X12

      UniProtKB/TrEMBL
      H7BX82
      Conserved Domains (2) summary
      smart00462
      Location:31190
      PTB; Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
      cd01269
      Location:193444
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain

    RNA

    1. XR_001781101.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173380.1: Suppressed sequence

      Description
      NM_173380.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.