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    Slc28a2b solute carrier family 28 member 2b [ Mus musculus (house mouse) ]

    Gene ID: 381417, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Slc28a2bprovided by MGI
    Official Full Name
    solute carrier family 28 member 2bprovided by MGI
    Primary source
    MGI:MGI:3702173
    See related
    Ensembl:ENSMUSG00000079071 AllianceGenome:MGI:3702173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm14085
    Summary
    Predicted to enable neurotransmitter transmembrane transporter activity and nucleoside transmembrane transporter activity. Predicted to be involved in several processes, including nucleoside transport; protein localization to cell surface; and purine nucleobase transmembrane transport. Predicted to be located in apicolateral plasma membrane; coated vesicle; and vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in small intestine adult (RPKM 11.0), large intestine adult (RPKM 7.3) and 7 other tissues See more
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    Genomic context

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    See Slc28a2b in Genome Data Viewer
    Location:
    2 E5; 2 60.63 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122315422..122358521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122484941..122528040)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7855 Neighboring gene BMP and activin membrane-bound inhibitor, pseudogene (Xenopus laevis) Neighboring gene STARR-positive B cell enhancer ABC_E11154 Neighboring gene predicted gene, 34325 Neighboring gene predicted gene, 17958 Neighboring gene glycine amidinotransferase (L-arginine:glycine amidinotransferase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine nucleobase transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine nucleoside transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine nucleoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyrimidine- and adenosine-specific:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inosine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine-containing compound transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in uridine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 28 (sodium-coupled nucleoside transporter), member 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085518.1 → NP_001078987.1  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2-like

      Status: VALIDATED

      Source sequence(s)
      AL954714
      Consensus CDS
      CCDS38223.1
      UniProtKB/TrEMBL
      A2AWR5, Q7TMQ0
      Related
      ENSMUSP00000106150.3, ENSMUST00000110521.3
      Conserved Domains (4) summary
      TIGR00804
      Location:176 → 587
      nupC; nucleoside transporter
      pfam01773
      Location:181 → 250
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:364 → 587
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:264 → 358
      Gate; Nucleoside recognition

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      122315422..122358521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319077.2 → XP_017174566.1  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2-like isoform X1

      Conserved Domains (1) summary
      TIGR00804
      Location:176 → 564
      nupC; nucleoside transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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