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    Cebpb CCAAT/enhancer binding protein beta [ Mus musculus (house mouse) ]

    Gene ID: 12608, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cebpbprovided by MGI
    Official Full Name
    CCAAT/enhancer binding protein betaprovided by MGI
    Primary source
    MGI:MGI:88373
    See related
    Ensembl:ENSMUSG00000056501 AllianceGenome:MGI:88373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta
    Summary
    Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and enzyme binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver development; regulation of leukocyte differentiation; and response to bacterium. Acts upstream of or within several processes, including mammary gland epithelium development; positive regulation of osteoblast differentiation; and regulation of gene expression. Located in chromosome; cytoplasm; and nuclear matrix. Part of C/EBP complex. Is expressed in several structures, including adrenal gland; connective tissue; extraembryonic component; genitourinary system; and integumental system. Used to study osteochondrodysplasia and viral infectious disease. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cebpb in Genome Data Viewer
    Location:
    2 H3; 2 87.58 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167530835..167532352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167688915..167690432)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7889 Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2657 Neighboring gene predicted gene 14320 Neighboring gene STARR-positive B cell enhancer ABC_E3421 Neighboring gene RIKEN cDNA A530013C23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:167549268-167549451 Neighboring gene predicted gene, 38464

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 1 cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in granuloma formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid cell development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of biomineral tissue development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of odontoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of odontoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of C/EBP complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of C/EBP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CHOP-C/EBP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex EXP
    Inferred from Experiment
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein beta
    Names
    AGP/EBP
    C/EBP BETA
    CCAAT/enhancer binding protein (C/EBP), beta
    interleukin-6-dependent-binding protein
    liver-enriched transcriptional activator
    nuclear protein Il6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287738.1NP_001274667.1  CCAAT/enhancer-binding protein beta isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (b, also known as LAP) represented in this RefSeq results from translation initiation at the second in-frame AUG start codon. Isoform b has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL935060
      UniProtKB/Swiss-Prot
      P28033
      Conserved Domains (1) summary
      cd14712
      Location:194264
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
    2. NM_001287739.1NP_001274668.1  CCAAT/enhancer-binding protein beta isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (c, also known as LIP) represented in this RefSeq results from translation initiation at the third in-frame AUG start codon. Isoform c has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL935060
      UniProtKB/Swiss-Prot
      P28033
      Conserved Domains (1) summary
      cd14712
      Location:64134
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain
    3. NM_009883.4NP_034013.1  CCAAT/enhancer-binding protein beta isoform a

      See identical proteins and their annotated locations for NP_034013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (a, also known as LAP*) represented in this RefSeq results from translation initiation at the 5' most AUG start codon and is the longest isoform.
      Source sequence(s)
      AL935060
      Consensus CDS
      CCDS17105.1
      UniProtKB/Swiss-Prot
      P28033
      UniProtKB/TrEMBL
      Q3UPN9
      Related
      ENSMUSP00000069850.4, ENSMUST00000070642.4
      Conserved Domains (1) summary
      cd14712
      Location:215285
      bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      167530835..167532352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)