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    C1rl complement component 1, r subcomponent-like [ Mus musculus (house mouse) ]

    Gene ID: 232371, updated on 27-Nov-2024

    Summary

    Official Symbol
    C1rlprovided by MGI
    Official Full Name
    complement component 1, r subcomponent-likeprovided by MGI
    Primary source
    MGI:MGI:2660692
    See related
    Ensembl:ENSMUSG00000038527 AllianceGenome:MGI:2660692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1rl1; C1rlp; C1r-LP
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Located in extracellular space. Is expressed in cartilage; stomach; and testis. Orthologous to human C1RL (complement C1r subcomponent like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 27.4), liver E18 (RPKM 8.7) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C1rl in Genome Data Viewer
    Location:
    6 F2; 6 59.16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124470072..124487602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124493113..124510643)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 5 Neighboring gene RIKEN cDNA D830015G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E3680 Neighboring gene calsyntenin 3 Neighboring gene predicted gene, 44096 Neighboring gene STARR-seq mESC enhancer starr_17296 Neighboring gene complement component 1, r subcomponent A Neighboring gene complement component 1, s subcomponent 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in blood microparticle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    complement C1r subcomponent-like protein
    Names
    C1r-like protein
    complement component 1, r subcomponent like protein
    NP_851989.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181344.5NP_851989.3  complement C1r subcomponent-like protein precursor

      See identical proteins and their annotated locations for NP_851989.3

      Status: VALIDATED

      Source sequence(s)
      AK133495, AK134207
      Consensus CDS
      CCDS20520.1
      UniProtKB/Swiss-Prot
      Q3UZ09, Q3V019, Q7TT43, Q7TT44
      Related
      ENSMUSP00000042883.10, ENSMUST00000049124.10
      Conserved Domains (3) summary
      smart00020
      Location:242474
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:50165
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:242477
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124470072..124487602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)