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    Kics2 KICSTOR subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 270802, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kics2provided by MGI
    Official Full Name
    KICSTOR subunit 2provided by MGI
    Primary source
    MGI:MGI:2670984
    See related
    Ensembl:ENSMUSG00000053684 AllianceGenome:MGI:2670984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030027L10
    Summary
    Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Predicted to be located in intercellular bridge and lysosome. Predicted to be part of KICSTOR complex. Orthologous to human KICS2 (KICSTOR subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 3.1), lung adult (RPKM 2.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kics2 in Genome Data Viewer
    Location:
    10 D2; 10 69.94 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121575835..121588770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121739930..121752865)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene STARR-seq mESC enhancer starr_28105 Neighboring gene predicted gene, 35865 Neighboring gene SLIT-ROBO Rho GTPase activating protein 1 Neighboring gene predicted gene, 46183 Neighboring gene STARR-seq mESC enhancer starr_28112 Neighboring gene predicted gene, 51787

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of KICSTOR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of KICSTOR complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of KICSTOR complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    KICSTOR subunit 2
    Names
    KICSTOR complex protein C12orf66 homolog
    UPF0536 protein C12orf66 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359720.1NP_001346649.1  KICSTOR subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124992, AK087110, BC065058, BY284944
      Consensus CDS
      CCDS88094.1
      UniProtKB/TrEMBL
      D3Z5F2
      Related
      ENSMUSP00000117249.2, ENSMUST00000136432.2
      Conserved Domains (1) summary
      pfam09404
      Location:1308
      DUF2003; Eukaryotic protein of unknown function (DUF2003)
    2. NM_173022.3NP_766610.2  KICSTOR subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_766610.2

      Status: VALIDATED

      Source sequence(s)
      AC124992, AK087110, BC065058
      Consensus CDS
      CCDS24213.1
      UniProtKB/Swiss-Prot
      Q3TE08, Q3TRB8, Q6P1I3, Q8C334
      Related
      ENSMUSP00000070834.8, ENSMUST00000065600.8
      Conserved Domains (1) summary
      pfam09404
      Location:10444
      DUF2003; Eukaryotic protein of unknown function (DUF2003)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      121575835..121588770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)