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    Cyb561 cytochrome b-561 [ Mus musculus (house mouse) ]

    Gene ID: 13056, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyb561provided by MGI
    Official Full Name
    cytochrome b-561provided by MGI
    Primary source
    MGI:MGI:103253
    See related
    Ensembl:ENSMUSG00000019590 AllianceGenome:MGI:103253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis and intracellular iron ion homeostasis. Located in chromaffin granule membrane. Is expressed in several structures, including genitourinary system; gut; nervous system; node; and nose. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 144.4), adrenal adult (RPKM 27.6) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cyb561 in Genome Data Viewer
    Location:
    11 E1; 11 68.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105824528..105844157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105933702..105945019, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane monodehydroascorbate reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane monodehydroascorbate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ascorbate homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ascorbate homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromaffin granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromaffin granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transmembrane ascorbate-dependent reductase CYB561
    Names
    CGCytb
    chromaffin granule Cyt b561
    cytochrome b561

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356374.2NP_001343303.1  transmembrane ascorbate-dependent reductase CYB561 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL596246
      Consensus CDS
      CCDS25542.1
      UniProtKB/Swiss-Prot
      Q3TEC6, Q60720, Q9D6C9
      UniProtKB/TrEMBL
      Q8CE89
      Conserved Domains (1) summary
      cl23723
      Location:43184
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    2. NM_001430914.1NP_001417843.1  transmembrane ascorbate-dependent reductase CYB561 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596246
      UniProtKB/TrEMBL
      V9GX11
    3. NM_001430915.1NP_001417844.1  transmembrane ascorbate-dependent reductase CYB561 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596246
      UniProtKB/TrEMBL
      V9GX11
    4. NM_007805.6NP_031831.2  transmembrane ascorbate-dependent reductase CYB561 isoform 1

      See identical proteins and their annotated locations for NP_031831.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL596246
      Consensus CDS
      CCDS25542.1
      UniProtKB/Swiss-Prot
      Q3TEC6, Q60720, Q9D6C9
      UniProtKB/TrEMBL
      Q8CE89
      Related
      ENSMUSP00000019734.5, ENSMUST00000019734.11
      Conserved Domains (1) summary
      cl23723
      Location:43184
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105824528..105844157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156276.1XP_036012169.1  transmembrane ascorbate-dependent reductase CYB561 isoform X1

      Conserved Domains (1) summary
      cd08763
      Location:81222
      Cyt_b561_CYB561; Vertebrate cytochrome b(561), CYB561 gene product
    2. XM_036156277.1XP_036012170.1  transmembrane ascorbate-dependent reductase CYB561 isoform X2

      UniProtKB/TrEMBL
      Q8CE89
      Conserved Domains (1) summary
      cl23723
      Location:53194
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    3. XM_006532131.4XP_006532194.1  transmembrane ascorbate-dependent reductase CYB561 isoform X3

      See identical proteins and their annotated locations for XP_006532194.1

      UniProtKB/Swiss-Prot
      Q3TEC6, Q60720, Q9D6C9
      UniProtKB/TrEMBL
      Q8CE89
      Conserved Domains (1) summary
      cl23723
      Location:43184
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    4. XM_006532132.5XP_006532195.1  transmembrane ascorbate-dependent reductase CYB561 isoform X3

      See identical proteins and their annotated locations for XP_006532195.1

      UniProtKB/Swiss-Prot
      Q3TEC6, Q60720, Q9D6C9
      UniProtKB/TrEMBL
      Q8CE89
      Conserved Domains (1) summary
      cl23723
      Location:43184
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    5. XM_036156278.1XP_036012171.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

      Conserved Domains (1) summary
      cl23723
      Location:43174
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    6. XM_036156279.1XP_036012172.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

      Conserved Domains (1) summary
      cl23723
      Location:43174
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    7. XM_006532134.5XP_006532197.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

      Related
      ENSMUSP00000138931.2, ENSMUST00000184086.8
      Conserved Domains (1) summary
      cl23723
      Location:43174
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...