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    Trim35 tripartite motif-containing 35 [ Mus musculus (house mouse) ]

    Gene ID: 66854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim35provided by MGI
    Official Full Name
    tripartite motif-containing 35provided by MGI
    Primary source
    MGI:MGI:1914104
    See related
    Ensembl:ENSMUSG00000022043 AllianceGenome:MGI:1914104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NC8; HLS5; Mair; mKIAA1098; 0710005M05Rik; A430106H13Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 102.9), adrenal adult (RPKM 97.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Trim35 in Genome Data Viewer
    Location:
    14 D1; 14 34.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66534474..66548873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66297025..66311424)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene STARR-positive B cell enhancer ABC_E7326 Neighboring gene STARR-seq mESC enhancer starr_36992 Neighboring gene predicted gene, 52098 Neighboring gene STARR-positive B cell enhancer ABC_E3121 Neighboring gene STARR-seq mESC enhancer starr_36993 Neighboring gene STARR-seq mESC enhancer starr_36994 Neighboring gene predicted gene, 52099 Neighboring gene STARR-positive B cell enhancer ABC_E7327 Neighboring gene STARR-seq mESC enhancer starr_36995 Neighboring gene RIKEN cDNA 1700001G11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66915655-66915915 Neighboring gene STARR-positive B cell enhancer ABC_E8565 Neighboring gene predicted gene, 41183 Neighboring gene stathmin-like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM35
    Names
    hemopoietic lineage switch protein 5
    macrophage-derived apoptosis-inducing RBCC protein
    protein Nc8
    tripartite motif-containing protein 35
    NP_084255.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029979.3NP_084255.2  E3 ubiquitin-protein ligase TRIM35

      See identical proteins and their annotated locations for NP_084255.2

      Status: VALIDATED

      Source sequence(s)
      AC140329, AF145374
      Consensus CDS
      CCDS27221.2
      UniProtKB/Swiss-Prot
      A6H681, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8C006, Q8VID4, Q9CW74, Q9D208
      UniProtKB/TrEMBL
      A0A0R4J031
      Related
      ENSMUSP00000022623.7, ENSMUST00000022623.13
      Conserved Domains (4) summary
      cd00021
      Location:114152
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13863
      Location:166262
      DUF4200; Domain of unknown function (DUF4200)
      cl02614
      Location:318504
      SPRY; SPRY domain
      cl17238
      Location:3377
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66534474..66548873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)