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    Plxnb2 plexin B2 [ Mus musculus (house mouse) ]

    Gene ID: 140570, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plxnb2provided by MGI
    Official Full Name
    plexin B2provided by MGI
    Primary source
    MGI:MGI:2154239
    See related
    Ensembl:ENSMUSG00000036606 AllianceGenome:MGI:2154239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Debt; plexin-B2
    Summary
    Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 85.9), ovary adult (RPKM 65.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Plxnb2 in Genome Data Viewer
    Location:
    15 E3; 15 44.68 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89039752..89064960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89155546..89182018, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene DENN domain containing 6B Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • mKIAA0315, 1110007H23Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in excitatory synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    plexin-B2
    Names
    differentially expressed in brain tumors

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159521.3NP_001152993.1  plexin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001152993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC113069, AC160538
      Consensus CDS
      CCDS49698.1
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
      Conserved Domains (7) summary
      cd01179
      Location:898984
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:806897
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:471519
      PSI; Plexin repeat
      pfam08337
      Location:12751809
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:528615
      TIG_plexin; TIG domain
      cl15674
      Location:9861069
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:27469
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    2. NM_001284506.2NP_001271435.1  plexin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001271435.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC113069, AC160538
      Consensus CDS
      CCDS49698.1
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
      Related
      ENSMUSP00000051731.10, ENSMUST00000060808.10
      Conserved Domains (7) summary
      cd01179
      Location:898984
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:806897
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:471519
      PSI; Plexin repeat
      pfam08337
      Location:12751809
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:528615
      TIG_plexin; TIG domain
      cl15674
      Location:9861069
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:27469
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    3. NM_001416425.1NP_001403354.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    4. NM_001416426.1NP_001403355.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    5. NM_001416427.1NP_001403356.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    6. NM_001416428.1NP_001403357.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    7. NM_001416429.1NP_001403358.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    8. NM_001416430.1NP_001403359.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    9. NM_001416431.1NP_001403360.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    10. NM_001416432.1NP_001403361.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    11. NM_001416433.1NP_001403362.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    12. NM_001416434.1NP_001403363.1  plexin-B2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
    13. NM_001416435.1NP_001403364.1  plexin-B2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
    14. NM_001416436.1NP_001403365.1  plexin-B2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
    15. NM_001416437.1NP_001403366.1  plexin-B2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC113069, AC160538
    16. NM_138749.4NP_620088.2  plexin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_620088.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC113069, AC160538
      Consensus CDS
      CCDS49698.1
      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
      Related
      ENSMUSP00000104955.2, ENSMUST00000109331.9
      Conserved Domains (7) summary
      cd01179
      Location:898984
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:806897
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:471519
      PSI; Plexin repeat
      pfam08337
      Location:12751809
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:528615
      TIG_plexin; TIG domain
      cl15674
      Location:9861069
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:27469
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89039752..89064960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248318.2XP_030104178.1  plexin-B2 isoform X1

      UniProtKB/Swiss-Prot
      B2RXS4, Q3UH76
      Conserved Domains (7) summary
      cd01179
      Location:898984
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:806897
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:471519
      PSI; Plexin repeat
      pfam08337
      Location:12751809
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:528615
      TIG_plexin; TIG domain
      cl15674
      Location:9861069
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:27469
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins