U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rprd1b regulation of nuclear pre-mRNA domain containing 1B [ Mus musculus (house mouse) ]

    Gene ID: 70470, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rprd1bprovided by MGI
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 1Bprovided by MGI
    Primary source
    MGI:MGI:1917720
    See related
    Ensembl:ENSMUSG00000027651 AllianceGenome:MGI:1917720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crept; 2610304G08Rik; 2810446G03Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity and identical protein binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription preinitiation complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Orthologous to human RPRD1B (regulation of nuclear pre-mRNA domain containing 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.4), limb E14.5 (RPKM 10.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rprd1b in Genome Data Viewer
    Location:
    2 H1; 2 78.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157870395..157920127)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158028475..158078207)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34402 Neighboring gene TELO2 interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157854071-157854293 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene RIKEN cDNA 2010009K17 gene Neighboring gene STARR-seq mESC enhancer starr_06227 Neighboring gene STARR-seq mESC enhancer starr_06228 Neighboring gene predicted gene, 34458 Neighboring gene transglutaminase 2, C polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA polymerase II promoter clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA polymerase II promoter clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 1B
    Names
    cell cycle-related and expression-elevated protein in tumor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291134.1NP_001278063.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform a

      See identical proteins and their annotated locations for NP_001278063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI843346, AK011979, AK013301, AK035806, AK045404, AK147930
      Consensus CDS
      CCDS71177.1
      UniProtKB/Swiss-Prot
      A2ACF2, A2ACF4, A2ACF5, A2ACF6, Q1WDE6, Q3U8H1, Q3UGH1, Q3USX3, Q6GTJ6, Q9CSU0
      Related
      ENSMUSP00000029180.8, ENSMUST00000029180.14
      Conserved Domains (2) summary
      cd17012
      Location:3131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:178324
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    2. NM_001291135.1NP_001278064.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the 3' region, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AI843346, AK011979, AK013301, AK147930, AK152125, BP753919
      Consensus CDS
      CCDS71176.1
      UniProtKB/Swiss-Prot
      Q9CSU0
      Related
      ENSMUSP00000105144.2, ENSMUST00000109518.8
      Conserved Domains (2) summary
      smart00582
      Location:8126
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      pfam16566
      Location:178284
      CREPT; Cell-cycle alteration and expression-elevated protein in tumour
    3. NM_001291136.1NP_001278065.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AI843346, AK011979, AK013301, AK045404, AK147930, BP753919
      UniProtKB/Swiss-Prot
      Q9CSU0
      Related
      ENSMUST00000156552.8
      Conserved Domains (1) summary
      pfam16566
      Location:49194
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    4. NM_027434.3NP_081710.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform b

      See identical proteins and their annotated locations for NP_081710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AI843346, AK011979, AK013301, AK045404, AK147930, BP753919
      Consensus CDS
      CCDS16984.1
      UniProtKB/TrEMBL
      A0A0R4J195
      Related
      ENSMUSP00000099412.4, ENSMUST00000103123.10
      Conserved Domains (2) summary
      cd17012
      Location:3131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:177323
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157870395..157920127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500163.2XP_006500226.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

      Related
      ENSMUSP00000118434.2, ENSMUST00000152452.8
      Conserved Domains (2) summary
      cd17012
      Location:3131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:178218
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    2. XM_011239773.3XP_011238075.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X4

      Conserved Domains (1) summary
      pfam16566
      Location:50196
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    3. XM_006500162.3XP_006500225.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1

      Conserved Domains (2) summary
      cd17012
      Location:3131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:177283
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor
    4. XM_030252069.2XP_030107929.1  regulation of nuclear pre-mRNA domain-containing protein 1B isoform X3

      Conserved Domains (2) summary
      cd17012
      Location:3131
      CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B
      pfam16566
      Location:177217
      CREPT; Cell-cycle alteration and expression-elevated protein in tumor

    RNA

    1. XR_004940727.1 RNA Sequence

    2. XR_004940728.1 RNA Sequence