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    Bpi bactericidal permeablility increasing protein [ Mus musculus (house mouse) ]

    Gene ID: 329547, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bpiprovided by MGI
    Official Full Name
    bactericidal permeablility increasing proteinprovided by MGI
    Primary source
    MGI:MGI:3045315
    See related
    Ensembl:ENSMUSG00000052922 AllianceGenome:MGI:3045315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bpifd1; 9230105K17Rik
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in several processes, including defense response to other organism; lipopolysaccharide-mediated signaling pathway; and negative regulation of cytokine production. Located in cytoplasm. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPI (bactericidal permeability increasing protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 29.4) and testis adult (RPKM 24.9) See more
    Orthologs
    NEW
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    Genomic context

    See Bpi in Genome Data Viewer
    Location:
    2 H1; 2 78.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158099983..158126453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158258063..158284533)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630003M21 gene Neighboring gene RIKEN cDNA 1700060C20 gene Neighboring gene microRNA 7685 Neighboring gene predicted gene, 34571 Neighboring gene lipopolysaccharide binding protein Neighboring gene small nucleolar RNA host gene 17 Neighboring gene predicted gene, 24411

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-8 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bactericidal permeability-increasing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356542.1NP_001343471.1  bactericidal permeability-increasing protein isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AY648037
      Consensus CDS
      CCDS89574.1
      UniProtKB/Swiss-Prot
      A2AC63, Q5I5I4, Q67E05, Q8BSF3
      Related
      ENSMUSP00000105125.2, ENSMUST00000109499.8
      Conserved Domains (2) summary
      smart00328
      Location:36259
      BPI1; BPI/LBP/CETP N-terminal domain
      cl00188
      Location:244482
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
    2. NM_177850.3NP_808518.1  bactericidal permeability-increasing protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_808518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK033770
      Consensus CDS
      CCDS16987.1
      UniProtKB/Swiss-Prot
      Q67E05
      Related
      ENSMUSP00000067837.3, ENSMUST00000065039.3
      Conserved Domains (2) summary
      smart00328
      Location:36259
      BPI1; BPI/LBP/CETP N-terminal domain
      cl00188
      Location:244485
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      158099983..158126453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319055.1XP_017174544.1  bactericidal permeability-increasing protein isoform X1

      Related
      ENSMUSP00000105126.2, ENSMUST00000109500.8
      Conserved Domains (2) summary
      smart00328
      Location:86309
      BPI1; BPI/LBP/CETP N-terminal domain
      cl00188
      Location:294531
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
    2. XM_017319056.2XP_017174545.1  bactericidal permeability-increasing protein isoform X2

      Conserved Domains (2) summary
      smart00328
      Location:34211
      BPI1; BPI/LBP/CETP N-terminal domain
      cl00188
      Location:196434
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...