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    Tomm34 translocase of outer mitochondrial membrane 34 [ Mus musculus (house mouse) ]

    Gene ID: 67145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tomm34provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 34provided by MGI
    Primary source
    MGI:MGI:1914395
    See related
    Ensembl:ENSMUSG00000018322 AllianceGenome:MGI:1914395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TOM34; 2610100K07Rik
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; olfactory epithelium; thymus primordium; and trigeminal ganglion. Orthologous to human TOMM34 (translocase of outer mitochondrial membrane 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.7), thymus adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tomm34 in Genome Data Viewer
    Location:
    2 H3; 2 84.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163895458..163913168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164053538..164071178, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3417 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene STARR-positive B cell enhancer ABC_E6014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163910112-163910326 Neighboring gene serine/threonine kinase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:163954265-163954566 Neighboring gene K+ voltage-gated channel, subfamily S, 1 Neighboring gene predicted gene, 53202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Tom34 splicing isoforms in mouse testis and knockout of Tom34 in mice. Terada K, et al. J Biochem, 2003 May. PMID 12801914
    2. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article
    3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    4. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM34
    Names
    translocase of outer membrane 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291155.1 → NP_001278084.1  mitochondrial import receptor subunit TOM34 isoform a

      See identical proteins and their annotated locations for NP_001278084.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tom34a) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant Tom34b. The encoded isoform (a, also known as Tomm34a) has a distinct N-terminus and is the same length as isoform b.
      Source sequence(s)
      AK017699, BB869739, BM937584
      Consensus CDS
      CCDS71187.1
      UniProtKB/Swiss-Prot
      A2A5N5, A2A5N6, Q3THD0, Q812F1, Q812F2, Q9CYG7, Q9D059
      Related
      ENSMUSP00000105010.4, ENSMUST00000109384.10
      Conserved Domains (3) summary
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:229 → 260
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:192 → 257
      TPR_11; TPR repeat

    2. NM_025996.5 → NP_080272.1  mitochondrial import receptor subunit TOM34 isoform b

      See identical proteins and their annotated locations for NP_080272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tom34b) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant Tom34a. The encoded isoform (b, also known as Tomm34b) has a distinct N-terminus and is the same length as isoform a.
      Source sequence(s)
      AK011786, AK017699, BM937584, CX235437
      Consensus CDS
      CCDS17020.1
      UniProtKB/Swiss-Prot
      Q9CYG7
      Related
      ENSMUSP00000018466.4, ENSMUST00000018466.4
      Conserved Domains (2) summary
      TIGR00990
      Location:12 → 294
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163895458..163913168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500067.2 → XP_006500130.1  mitochondrial import receptor subunit TOM34 isoform X1

      See identical proteins and their annotated locations for XP_006500130.1

      UniProtKB/Swiss-Prot
      Q9CYG7
      Conserved Domains (2) summary
      TIGR00990
      Location:12 → 294
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_374511.5 RNA Sequence

    2. XR_003953697.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYG7.1 GenPept UniProtKB/Swiss-Prot:Q9CYG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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