Replication interactions
Interaction |
Pubs |
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRAS |
PubMed
|
Knockdown of neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp160, precursor
|
env
|
Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells |
PubMed
|
|
env
|
HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation |
PubMed
|
Nef
|
nef
|
HIV-1 Nef-induced relocalization of LCK is correlated with N-Ras activation at recycling endosome/TGN compartments |
PubMed
|
Tat
|
tat
|
HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat |
PubMed
|
|
tat
|
Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing |
PubMed
|
Go to the HIV-1, Human Interaction Database