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    Rusc2 RUN and SH3 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684259, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rusc2provided by RGD
    Official Full Name
    RUN and SH3 domain containing 2provided by RGD
    Primary source
    RGD:1592688
    See related
    EnsemblRapid:ENSRNOG00000045843 AllianceGenome:RGD:1592688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be active in cytoplasmic vesicle. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC2 (RUN and SH3 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 99.8), Lung (RPKM 75.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rusc2 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62424185..62471317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57628397..57675524)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58860444..58883152)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene unc-13 homolog B Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene uncharacterized LOC120102860 Neighboring gene uncharacterized LOC134486932 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene testis associated actin remodelling kinase 1 Neighboring gene Cd72 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Iporin as a novel interaction partner for rab1. Bayer M, et al. BMC Cell Biol, 2005 Mar 29. PMID 15796781, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex accessory subunit RUSC2
    Names
    iporin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427205.1 → NP_001414134.1  AP-4 complex accessory subunit RUSC2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      M0RCV5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      62424185..62471317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111004.2 → XP_038966932.1  AP-4 complex accessory subunit RUSC2 isoform X2

      Conserved Domains (3) summary
      pfam02759
      Location:162 → 265
      RUN; RUN domain
      cl15692
      Location:36 → 140
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
      cl17036
      Location:574 → 625
      SH3; Src Homology 3 domain superfamily

    2. XM_039110999.2 → XP_038966927.1  AP-4 complex accessory subunit RUSC2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY69, M0RCV5
      Conserved Domains (4) summary
      PHA03247
      Location:507 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam02759
      Location:1039 → 1142
      RUN; RUN domain
      cl15692
      Location:913 → 1017
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
      cl17036
      Location:1451 → 1502
      SH3; Src Homology 3 domain superfamily

    3. XM_039111001.2 → XP_038966929.1  AP-4 complex accessory subunit RUSC2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY69, M0RCV5
      Conserved Domains (4) summary
      PHA03247
      Location:507 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam02759
      Location:1039 → 1142
      RUN; RUN domain
      cl15692
      Location:913 → 1017
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
      cl17036
      Location:1451 → 1502
      SH3; Src Homology 3 domain superfamily

    4. XM_039111000.2 → XP_038966928.1  AP-4 complex accessory subunit RUSC2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY69, M0RCV5
      Related
      ENSRNOP00000067440.3, ENSRNOT00000072869.4
      Conserved Domains (4) summary
      PHA03247
      Location:507 → 895
      PHA03247; large tegument protein UL36; Provisional
      pfam02759
      Location:1039 → 1142
      RUN; RUN domain
      cl15692
      Location:913 → 1017
      CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
      cl17036
      Location:1451 → 1502
      SH3; Src Homology 3 domain superfamily

    5. XM_039111003.2 → XP_038966931.2  AP-4 complex accessory subunit RUSC2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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