Sgpp1 sphingosine-1-phosphate phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgpp1provided by MGI
Official Full Name: sphingosine-1-phosphate phosphatase 1provided by MGI
Primary source: MGI:MGI:2135760
See related: Ensembl:ENSMUSG00000021054 AllianceGenome:MGI:2135760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPP; SPP1; Spph1
Summary: Enables sphingosine-1-phosphate phosphatase activity. Involved in regulation of keratinocyte differentiation. Acts upstream of or within apoptotic signaling pathway and sphingolipid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including adrenal gland; alimentary system; heart; liver; and urinary system. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 78.6), genital fat pad adult (RPKM 72.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 32.95 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (75761022..75782503, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (75714248..75735729, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that Runx1 regulates glucocorticoid sensitivity in lymphoma cells and identify an established direct target gene, Sgpp1, as an integrator of sphingolipid metabolism and responses to glucocorticoids.
Title: Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.
Data indicate that sphingosine-1-phosphate phosphatases 1 (Sgpp1) deficiency in keratinocytes causes sphingosine-1-phosphate (S1P) elevation and accelerates their differentiation.
Title: Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis.
sphingosine-1-phosphate phosphatase 1 plays roles in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
Title: Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.
regulation of sphingolipid metabolism and apoptosis by SPP1
Title: Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236876

Sgpp1 (e-PCR), detects polymorphism
- UniSTS:496530

RH136984 (e-PCR)
- UniSTS:219073

AI463453 (e-PCR)
- UniSTS:160217

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dihydrosphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	ISO Inferred from Sequence Orthology more info
involved_in ER to Golgi ceramide transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sphinganine-1-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sphingolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sphingosine metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
NOT located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sphingosine-1-phosphate phosphatase 1

Names: SPPase1; sphingosine-1-phosphatase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030750.3 → NP_109675.1 sphingosine-1-phosphate phosphatase 1

See identical proteins and their annotated locations for NP_109675.1

Status: VALIDATED

Source sequence(s)

AC124742, AK149860

Consensus CDS

CCDS25986.1

UniProtKB/Swiss-Prot

Q9JI99

UniProtKB/TrEMBL

Q3UDY2

Related

ENSMUSP00000021450.5, ENSMUST00000021450.6

Conserved Domains (1) summary

cd03388
Location:117 → 264

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...