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    Hrg histidine-rich glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 94175, updated on 13-Jan-2025

    Summary

    Official Symbol
    Hrgprovided by MGI
    Official Full Name
    histidine-rich glycoproteinprovided by MGI
    Primary source
    MGI:MGI:2146636
    See related
    Ensembl:ENSMUSG00000022877 AllianceGenome:MGI:2146636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hprg; Hrgp; D16jh2; D18020
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including defense response to other organism; negative regulation of blood vessel endothelial cell migration; and positive regulation of blood vessel remodeling. Acts upstream of or within negative regulation of fibrinolysis. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward liver adult (RPKM 112.7) See more
    Orthologs
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    Genomic context

    See Hrg in Genome Data Viewer
    Location:
    16 B1; 16 13.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22769822..22780409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22951072..22961659)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30611 Neighboring gene fetuin beta Neighboring gene STARR-seq mESC enhancer starr_40421 Neighboring gene STARR-seq mESC enhancer starr_40422 Neighboring gene kininogen 2 Neighboring gene STARR-seq mESC enhancer starr_40423 Neighboring gene STARR-seq mESC enhancer starr_40424 Neighboring gene transportin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40425 Neighboring gene tryptophan rich basic protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity  
    enables heme binding  
    enables heme binding  
    enables heparan sulfate proteoglycan binding  
    enables heparan sulfate proteoglycan binding  
    enables heparin binding  
    enables heparin binding  
    enables heparin binding  
    enables immunoglobulin binding  
    enables immunoglobulin binding  
    enables metal ion binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 51
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in chemotaxis  
    involved_in cytolysis by host of symbiont cells  
    involved_in defense response to fungus PubMed 
    involved_in defense response to fungus  
    acts_upstream_of fibrinolysis PubMed 
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of blood vessel endothelial cell migration PubMed 
    involved_in negative regulation of cell adhesion  
    involved_in negative regulation of cell adhesion  
    involved_in negative regulation of cell adhesion mediated by integrin  
    involved_in negative regulation of cell adhesion mediated by integrin  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of endothelial cell chemotaxis  
    involved_in negative regulation of endothelial cell chemotaxis  
    involved_in negative regulation of fibrinolysis  
    acts_upstream_of_or_within negative regulation of fibrinolysis PubMed 
    involved_in negative regulation of lamellipodium assembly  
    involved_in negative regulation of lamellipodium assembly  
    involved_in negative regulation of vascular endothelial growth factor signaling pathway  
    involved_in negative regulation of vascular endothelial growth factor signaling pathway  
    involved_in platelet activation  
    involved_in platelet activation  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of blood vessel remodeling PubMed 
    involved_in positive regulation of blood vessel remodeling  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of immune response to tumor cell  
    involved_in positive regulation of immune response to tumor cell PubMed 
    involved_in positive regulation of immune response to tumor cell  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of blood coagulation PubMed 
    involved_in regulation of blood coagulation  
    involved_in regulation of gene expression PubMed 
    involved_in regulation of gene expression  
    involved_in regulation of peptidyl-tyrosine phosphorylation  
    involved_in regulation of peptidyl-tyrosine phosphorylation  
    involved_in regulation of platelet activation  
    involved_in regulation of platelet activation PubMed 
    involved_in regulation of protein-containing complex assembly  
    involved_in regulation of protein-containing complex assembly  
    Items 1 - 25 of 51
    Component Evidence Code Pubs
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in extracellular region  
    located_in extracellular region  
    located_in extracellular region  

    General protein information

    Preferred Names
    histidine-rich glycoprotein
    Names
    histidine-proline-rich glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053176.2NP_444406.2  histidine-rich glycoprotein precursor

      See identical proteins and their annotated locations for NP_444406.2

      Status: VALIDATED

      Source sequence(s)
      AI182388, AI196096, AI303163, CB593922, CB946752
      Consensus CDS
      CCDS49800.1
      UniProtKB/Swiss-Prot
      Q6YK32, Q6YKA2, Q99PS5, Q99PS6, Q9ESB3
      UniProtKB/TrEMBL
      A0A0R4J039
      Related
      ENSMUSP00000023590.9, ENSMUST00000023590.9
      Conserved Domains (1) summary
      cl09238
      Location:30131
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22769822..22780409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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