U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACAT1 acetyl-CoA acetyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 38, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ACAT1provided by HGNC
    Official Full Name
    acetyl-CoA acetyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:93
    See related
    Ensembl:ENSG00000075239 MIM:607809; AllianceGenome:HGNC:93
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2; MAT; ACAT; THIL
    Summary
    This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]
    Annotation information
    Note: ACAT1 (Gene ID: 38) and SOAT1 (Gene ID: 6646) share the ACAT1 symbol/alias in common. ACAT1 is a widely used alternative name for sterol O-acyltransferase 1 (SOAT1), which can be confused with the official symbol for ACAT1 (acetyl-CoA acetyltransferase 1, GeneID 38). [01 Jun 2018]
    Expression
    Broad expression in liver (RPKM 166.9), kidney (RPKM 164.2) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ACAT1 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (108116705..108147603)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (108124245..108155151)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (107987432..108018330)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5479 Neighboring gene Sharpr-MPRA regulatory region 4319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5480 Neighboring gene cullin 5 Neighboring gene uncharacterized LOC124902748 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:107991956-107992494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5482 Neighboring gene MPRA-validated peak1447 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr11:108021496-108021664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3877 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:108047982 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:108089151 Neighboring gene NANOG hESC enhancer GRCh37_chr11:108089784-108090285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5487 Neighboring gene MPRA-validated peak1449 silencer Neighboring gene MPRA-validated peak1450 silencer Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:108140516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:108147863-108148662 Neighboring gene ATM serine/threonine kinase Neighboring gene chromosome 11 open reading frame 65 Neighboring gene MPRA-validated peak1451 silencer

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of Alu-mediated, large deletion-spanning exons 2-4 in a patient with mitochondrial acetoacetyl-CoA thiolase deficiency. Zhang G, et al. Mol Genet Metab, 2006 Nov. PMID 16935016
    2. Beta-ketothiolase deficiency in a family confirmed by in vitro enzymatic assays in fibroblasts. Schutgens RB, et al. Eur J Pediatr, 1982 Sep. PMID 7173255
    3. Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients. Wakazono A, et al. Hum Mutat, 1995. PMID 7728148
    4. Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene. Fukao T, et al. Hum Mutat, 1995. PMID 7749408
    5. Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency. Fukao T, et al. J Clin Invest, 1994 Mar. PMID 7907600, Free PMC Article

    See all (168) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer.
      Title: From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer.
    2. [Clinical analysis and genetic diagnosis of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes].
      Title: [Clinical analysis and genetic diagnosis of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes].
    3. Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression.
      Title: Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression.
    4. Elevated serum beta-hydroxybutyrate, a circulating ketone metabolite, accelerates colorectal cancer proliferation and metastasis via ACAT1.
      Title: Elevated serum β-hydroxybutyrate, a circulating ketone metabolite, accelerates colorectal cancer proliferation and metastasis via ACAT1.
    5. ACAT1-mediated METTL3 acetylation inhibits cell migration and invasion in triple negative breast cancer.
      Title: ACAT1-mediated METTL3 acetylation inhibits cell migration and invasion in triple negative breast cancer.
    6. Association between ACAT1 rs1044925 and increased hypertension risk in Tongdao Dong.
      Title: Association between ACAT1 rs1044925 and increased hypertension risk in Tongdao Dong.
    7. Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer.
      Title: Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer.
    8. Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma.
      Title: Epigenetic inactivation of ACAT1 promotes epithelial-mesenchymal transition of clear cell renal cell carcinoma.
    9. Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
      Title: Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
    10. Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
      Title: Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Deficiency of acetyl-CoA acetyltransferase
    MedGen: C1536500 OMIM: 203750 GeneReviews: Not available
    		Compare labs

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of acetyl-CoA acetyltransferase 1 (ACAT1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA C-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA C-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetyl-CoA C-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cholesterol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coenzyme A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acetyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoleucine catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ketone body catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ketone body metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metanephric proximal convoluted tubule development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    acetyl-CoA acetyltransferase, mitochondrial
    Names
    acetoacetyl Coenzyme A thiolase
    acetoacetyl-CoA thiolase
    acetyl-Coenzyme A acetyltransferase 1
    mitochondrial acetoacetyl-CoA thiolase
    testicular tissue protein Li 198
    NP_000010.1
    NP_001373606.1
    NP_001373607.1
    NP_001373608.1
    NP_001373610.1
    NP_001373611.1
    NP_001373614.1
    NP_001373615.1
    NP_001373616.1
    NP_001373617.1
    NP_001373618.1
    NP_001373619.1
    NP_001373620.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009888.2 RefSeqGene

      Range
      9863..35899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1400

    mRNA and Protein(s)

    1. NM_000019.4 → NP_000010.1  acetyl-CoA acetyltransferase, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_000010.1

      Status: REVIEWED

      Source sequence(s)
      AW081574, D90228
      Consensus CDS
      CCDS8339.1
      UniProtKB/Swiss-Prot
      B2R6H1, G3XAB4, P24752, Q96FG8
      UniProtKB/TrEMBL
      A0A140VJX1
      Related
      ENSP00000265838.4, ENST00000265838.9
      Conserved Domains (1) summary
      cd00751
      Location:43 → 426
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    2. NM_001386677.1 → NP_001373606.1  acetyl-CoA acetyltransferase, mitochondrial isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91579.1
      UniProtKB/TrEMBL
      A0A5F9ZHL1
      Related
      ENSP00000500490.1, ENST00000672354.1
      Conserved Domains (1) summary
      cd00751
      Location:43 → 433
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    3. NM_001386678.1 → NP_001373607.1  acetyl-CoA acetyltransferase, mitochondrial isoform c

      Status: REVIEWED

      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91580.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZI66
      Related
      ENSP00000500928.1, ENST00000672907.2
      Conserved Domains (1) summary
      cd00751
      Location:41 → 321
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    4. NM_001386679.1 → NP_001373608.1  acetyl-CoA acetyltransferase, mitochondrial isoform d

      Status: REVIEWED

      Source sequence(s)
      AP002433
      UniProtKB/TrEMBL
      A0A5F9ZHD4
      Conserved Domains (1) summary
      cd00751
      Location:10 → 327
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    5. NM_001386681.1 → NP_001373610.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 6-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Related
      ENSP00000500444.1, ENST00000672284.1
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    6. NM_001386682.1 → NP_001373611.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 5 and 7-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    7. NM_001386685.1 → NP_001373614.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 5, 6, and 8-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Related
      ENSP00000500163.1, ENST00000673531.1
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    8. NM_001386686.1 → NP_001373615.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 5-7 and 9-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    9. NM_001386687.1 → NP_001373616.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 5-8 and 10-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    10. NM_001386688.1 → NP_001373617.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 5-9 and 11-13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    11. NM_001386689.1 → NP_001373618.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 5-10, 12, and 13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    12. NM_001386690.1 → NP_001373619.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 5-11 and 13, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    13. NM_001386691.1 → NP_001373620.1  acetyl-CoA acetyltransferase, mitochondrial isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 5-12, encodes isoform e.
      Source sequence(s)
      AP002433
      Consensus CDS
      CCDS91581.1
      UniProtKB/TrEMBL
      A0A5F9ZHD4, A0A5F9ZHJ0
      Conserved Domains (1) summary
      cd00751
      Location:1 → 336
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    RNA

    1. NR_170162.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002433
      Related
      ENST00000672031.1

    2. NR_170163.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002433

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      108116705..108147603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      108124245..108155151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24752.1 GenPept UniProtKB/Swiss-Prot:P24752

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous