THORLNC testis associated oncogenic lncRNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: THORLNCprovided by HGNC
Official Full Name: testis associated oncogenic lncRNAprovided by HGNC
Primary source: HGNC:HGNC:53788
See related: Ensembl:ENSG00000226856 MIM:619296; AllianceGenome:HGNC:53788
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: THOR
Expression: Restricted expression toward testis (RPKM 7.6) See more
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Genomic context

Location:: 2q14.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (118182922..118186386, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (118616222..118619693, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (118940498..118943962, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
Title: The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
LncRNA THOR promotes endometrial cancer progression through the AKT and ERK signaling pathways.
Title: LncRNA THOR promotes endometrial cancer progression through the AKT and ERK signaling pathways.
Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR/IGF2BP1 axis.
Title: Carboxymethylated chitosan alleviated oxidative stress injury in retinal ganglion cells via IncRNA-THOR/IGF2BP1 axis.
Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating beta-Catenin Signaling.
Title: Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling.
A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Title: A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.
Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
Title: Lnc-THOR silencing inhibits human glioma cell survival by activating MAGEA6-AMPK signaling.
THOR mediated IGF2 expression via interacting with IGF2BP1, and affected the downstream MEK-ERK signaling pathway to regulate tongue squamous cell carcinomas cells proliferation.
Title: LncRNA THOR promotes tongue squamous cell carcinomas by stabilizing IGF2BP1 downstream targets.
THOR expression promotes renal cell carcinoma cell growth in vitro and in vivo.
Title: LncRNA THOR promotes human renal cell carcinoma cell growth.
THOR could potentiate the stemness of gastric cancer cells via directly binding to SOX9 3'UTR.
Title: LncRNA THOR increases the stemness of gastric cancer cells via enhancing SOX9 mRNA stability.
lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells by up-regulating c-myc and TGF2BP1 expression.
Title: LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

testis-associated highly-conserved oncogenic long non-coding RNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.