CYLD CYLD lysine 63 deubiquitinase [Gallus gallus (chicken)] - Gene

Summary

Symbol: CYLDprovided by CGNC
Full Name: CYLD lysine 63 deubiquitinaseprovided by CGNC
Primary source: CGNC:2744
See related: Ensembl:ENSGALG00010022737
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	11	NC_052542.1 (5797488..5878998, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	11	NC_052583.1 (6137641..6220400, complement)

Chromosome 11 - NC_052542.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ADL135 (e-PCR)
- UniSTS:14389

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase CYLD

Names: cylindromatosis (turban tumor syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5797488..5878998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046899708.1 → XP_046755664.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9
XM_046899707.1 → XP_046755663.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9
XM_040707151.2 → XP_040563085.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8V0ZPP9

Related

ENSGALP00010033455.1, ENSGALT00010055283.1

Conserved Domains (2) summary

smart01052
Location:426 → 493

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:546 → 901

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040707149.2 → XP_040563083.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040707150.2 → XP_040563084.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8V0ZPP9

Related

ENSGALP00010033462.1, ENSGALT00010055292.1

Conserved Domains (2) summary

smart01052
Location:426 → 493

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:546 → 901

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040707147.2 → XP_040563081.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040707148.2 → XP_040563082.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Related

ENSGALP00010033458.1, ENSGALT00010055288.1

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_015292398.4 → XP_015147884.3 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_046899709.1 → XP_046755665.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

6137641..6220400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046925744.1 → XP_046781700.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9
XM_046925742.1 → XP_046781698.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9
XM_046925743.1 → XP_046781699.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9
XM_040680812.2 → XP_040536746.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:426 → 493

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:546 → 901

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040680808.2 → XP_040536742.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040680810.2 → XP_040536744.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/TrEMBL

A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:426 → 493

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:546 → 901

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040680806.2 → XP_040536740.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040680807.2 → XP_040536741.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_040680809.2 → XP_040536743.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9

Conserved Domains (2) summary

smart01052
Location:471 → 538

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:591 → 946

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_046925745.1 → XP_046781701.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

UniProtKB/TrEMBL

A0A8V0ZJC8, A0A8V0ZPP9