These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001277844.3 → NP_001264773.1  protein N-lysine methyltransferase METTL21A isoform a

   Status: VALIDATED

   Description

   Transcript Variant: This variant (1) encodes the longest isoform (a).

   Source sequence(s)

   JAENSK010000236

   UniProtKB/TrEMBL

   F1NVP6

   Related

   ENSGALP00010038199.1, ENSGALT00010061875.1

   Conserved Domains (1) summary

   cl17173
   Location:24 → 188

   AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

2. NM_001277845.3 → NP_001264774.1  protein N-lysine methyltransferase METTL21A isoform b

   See identical proteins and their annotated locations for NP_001264774.1

   Status: VALIDATED

   Description

   Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).

   Source sequence(s)

   JAENSK010000236

   UniProtKB/TrEMBL

   A0A1L1RWM7

   Conserved Domains (1) summary

   cl17173
   Location:2 → 132

   AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

3. NM_001277846.3 → NP_001264775.1  protein N-lysine methyltransferase METTL21A isoform b

   See identical proteins and their annotated locations for NP_001264775.1

   Status: VALIDATED

   Description

   Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 6 all encode the same isoform (b).

   Source sequence(s)

   JAENSK010000236

   UniProtKB/TrEMBL

   A0A1L1RWM7

   Conserved Domains (1) summary

   cl17173
   Location:2 → 132

   AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

4. NM_001277848.2 → NP_001264777.1  protein N-lysine methyltransferase METTL21A isoform c

   See identical proteins and their annotated locations for NP_001264777.1

   Status: VALIDATED

   Description

   Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a. Variants 4 and 7 both encode the same isoform (c).

   Source sequence(s)

   JAENSK010000236

   Conserved Domains (1) summary

   cl17173
   Location:2 → 29

   AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

5. NM_001277849.3 → NP_001264778.1  protein N-lysine methyltransferase METTL21A isoform d

   Status: VALIDATED

   Description

   Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.

   Source sequence(s)

   JAENSK010000236

   Conserved Domains (1) summary

   cl17173
   Location:24 → 85

   AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

   Range

   11796320..11802396

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_046943585.1 → XP_046799541.1  protein N-lysine methyltransferase METTL21A isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

   Range

   11717115..11723191

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_046921352.1 → XP_046777308.1  protein N-lysine methyltransferase METTL21A isoform X1

The following Reference Sequences have been suppressed. Explain

These RefSeqs were suppressed for the cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links, or BLAST links (BLink), but may still be retrieved by clicking on their accession.version below.

1. NM_001277850.1: Suppressed sequence

   Description

   NM_001277850.1: This RefSeq was removed because currently there is insufficient support for the transcript.

2. NM_001277852.1: Suppressed sequence

   Description

   NM_001277852.1: This RefSeq was removed because currently there is insufficient support for the transcript.