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    RAD18 RAD18, E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

    Gene ID: 416114, updated on 17-Aug-2024

    Summary

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    Symbol
    RAD18provided by CGNC
    Full Name
    RAD18, E3 ubiquitin protein ligaseprovided by CGNC
    Primary source
    CGNC:6341
    See related
    Ensembl:ENSGALG00010019584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RAD18 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19478609..19512884, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (19516712..19551007, complement)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene uncharacterized LOC121106670 Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene uncharacterized LOC121106669

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin. Yoshimura A, et al. DNA Repair (Amst), 2006 Nov 8. PMID 16931176
    2. Involvement of Rad18 in somatic hypermutation. Bachl J, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873544, Free PMC Article
    3. Functional relationships between Rad18 and WRNIP1 in vertebrate cells. Yoshimura A, et al. Biol Pharm Bull, 2006 Nov. PMID 17077513
    4. RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Saberi A, et al. Mol Cell Biol, 2007 Apr. PMID 17242200, Free PMC Article
    5. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Higher-eukaryotic cells separately employ PARP1 and Rad18 to suppress the toxic effects of NHEJ during the HR reaction at stalled replication forks.
      Title: RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
    2. Rad18 has a role in somatic hypermutation
      Title: Involvement of Rad18 in somatic hypermutation.
    3. RAD18 has a role in the protection of the genome from DNA damage.
      Title: A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in postreplication repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rad6-Rad18 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RAD18
    Names
    RAD18 homolog
    NP_001025774.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030603.3 → NP_001025774.2  E3 ubiquitin-protein ligase RAD18

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000252
      UniProtKB/TrEMBL
      A0A8V0ZHG7, Q5ZIP0
      Related
      ENSGALP00010028018.1, ENSGALT00010047272.1
      Conserved Domains (1) summary
      TIGR00599
      Location:13 → 311
      rad18; DNA repair protein rad18

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      19478609..19512884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      19516712..19551007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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