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    RUNX2 runt related transcription factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 373919, updated on 3-Dec-2024

    Summary

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    Symbol
    RUNX2provided by CGNC
    Full Name
    runt related transcription factor 2provided by CGNC
    Primary source
    CGNC:12522
    See related
    Ensembl:ENSGALG00010008166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RUNX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (109094477..109310203)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (108857336..109072853)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110154 Neighboring gene uncharacterized LOC121110155 Neighboring gene SPT3 homolog, SAGA and STAGA complex Neighboring gene uncharacterized LOC124417815 Neighboring gene uncharacterized LOC107053175 Neighboring gene chloride intracellular channel 5 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo. Tavares ALP, et al. Dev Dyn, 2018 Mar. PMID 28631378, Free PMC Article
    2. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Li TF, et al. Exp Cell Res, 2004 Sep 10. PMID 15302580
    3. Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line. Grupioni NV, et al. Genet Mol Res, 2017 Mar 22. PMID 28340265
    4. The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers. Paludo E, et al. Animal, 2017 Jun. PMID 27881195
    5. Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development. Chu D, et al. Biol Open, 2020 Oct 6. PMID 32917762, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data introduce the RUNX2-I isoform as a critical early transcription factor mediating EMT in the developing heart after induction by TGFbeta2.
      Title: Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo.
    2. This result indicates that the downregulation of RUNX2 and SPARC can contribute to an increased incidence of Bacterial chondronecrosis with osteomyelitis (BCO) in broilers.
      Title: The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers.
    3. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Genetic associations (P < 0.05) were found between SNP g.124,883A>G in the RUNX2 gene and chilled femur weigh and with performance traits.Selection based on g.124,883A>G in RUNX2 could be used to improve performance quality traits
      Title: Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line.
    4. during endochondral bone formation, Lbh may negatively regulate vascular invasion and formation of the early ossification center at least in part by interfering with Runx2 and/or VEGF expression
      Title: The transcriptional cofactor Lbh regulates angiogenesis and endochondral bone formation during fetal bone development.
    5. chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and Runx2/Smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates.
      Title: Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.
    6. Results describe crosstalk between bone morphogenetic protein-2-associated Smad1 and Runx2 during chondrocyte differentiation and dependence upon both signals for induction of the type X collagen promoter.
      Title: Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.
    7. PTHrP downregulates Runx2 expression primarily through the PKA signaling pathway.
      Title: Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.
    8. Over-expression of Wnt8c and Wnt9a, upregulated type X collagen (col10a1) and Runx2 mRNA expression thereby inducing chondrocyte hypertrophy.
      Title: Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    runt-related transcription factor 2
    Names
    Transcription factor RUNX2/CBFA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204128.2 → NP_989459.1  runt-related transcription factor 2

      See identical proteins and their annotated locations for NP_989459.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000070, MW036689
      UniProtKB/TrEMBL
      Q8UVG3, Q8UWC8
      Conserved Domains (3) summary
      pfam05109
      Location:238 → 432
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00853
      Location:78 → 204
      Runt; Runt domain
      pfam08504
      Location:381 → 472
      RunxI; Runx inhibition domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      109094477..109310203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015285080.4 → XP_015140566.2  runt-related transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y4R0
      Related
      ENSGALP00010011048.1, ENSGALT00010019500.1
      Conserved Domains (1) summary
      PHA03247
      Location:198 → 538
      PHA03247; large tegument protein UL36; Provisional

    2. XM_015285082.4 → XP_015140568.2  runt-related transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y4R0
      Conserved Domains (1) summary
      PHA03247
      Location:197 → 480
      PHA03247; large tegument protein UL36; Provisional

    3. XM_040696694.2 → XP_040552628.1  runt-related transcription factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XWI3
      Related
      ENSGALP00010011044.1, ENSGALT00010019496.1
      Conserved Domains (3) summary
      pfam00853
      Location:78 → 204
      Runt; Runt domain
      pfam08504
      Location:323 → 414
      RunxI; Runx inhibition domain
      pfam10428
      Location:139 → 336
      SOG2; RAM signalling pathway protein

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      108857336..109072853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046912848.1 → XP_046768804.1  runt-related transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y4R0

    2. XM_046912849.1 → XP_046768805.1  runt-related transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y4R0

    3. XM_046912850.1 → XP_046768806.1  runt-related transcription factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0XWI3
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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