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    SLC25A12 solute carrier family 25 member 12 [ Gallus gallus (chicken) ]

    Gene ID: 431387, updated on 3-Dec-2024

    Summary

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    Symbol
    SLC25A12provided by CGNC
    Full Name
    solute carrier family 25 member 12provided by CGNC
    Primary source
    CGNC:7264
    See related
    Ensembl:ENSGALG00010022751
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SLC25A12 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (17537597..17583072)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (17456121..17502113)

    Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene distal-less homeobox 1 Neighboring gene histone acetyltransferase 1 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene methyltransferase like 8 Neighboring gene cytochrome b reductase 1 Neighboring gene DDB1 and CUL4 associated factor 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in malate-aspartate shuttle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-binding mitochondrial carrier protein Aralar1
    Names
    solute carrier family 25 (aspartate/glutamate carrier), member 12
    solute carrier family 25 (mitochondrial carrier, Aralar), member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      17537597..17583072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046944083.1 → XP_046800039.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZSJ0
      Related
      ENSGALP00010033492.1, ENSGALT00010055329.1

    2. XM_015289764.4 → XP_015145250.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZSH0
      Related
      ENSGALP00010033479.1, ENSGALT00010055312.1
      Conserved Domains (5) summary
      COG5126
      Location:150 → 220
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:332 → 605
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:92 → 117
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:92 → 161
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
      cl08302
      Location:19 → 81
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_015289765.4 → XP_015145251.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZSH0
      Related
      ENSGALP00010033477.1, ENSGALT00010055309.1
      Conserved Domains (5) summary
      COG5126
      Location:149 → 219
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:331 → 604
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:91 → 116
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:91 → 160
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
      cl08302
      Location:18 → 80
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_046944084.1 → XP_046800040.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0ZSH0
      Related
      ENSGALP00010033489.1, ENSGALT00010055325.1

    5. XM_046944085.1 → XP_046800041.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0ZPS8

    6. XM_025152606.3 → XP_025008374.2  calcium-binding mitochondrial carrier protein Aralar1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZPS8
      Conserved Domains (4) summary
      COG5126
      Location:122 → 192
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:304 → 577
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:64 → 89
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:64 → 133
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

    7. XM_025152607.3 → XP_025008375.2  calcium-binding mitochondrial carrier protein Aralar1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0ZPS8, A0A8V0ZSI4
      Related
      ENSGALP00010033487.1, ENSGALT00010055322.1
      Conserved Domains (4) summary
      COG5126
      Location:117 → 187
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:299 → 572
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:59 → 84
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:59 → 128
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      17456121..17502113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046921950.1 → XP_046777906.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZSJ0

    2. XM_040676718.2 → XP_040532652.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZSH0
      Conserved Domains (5) summary
      COG5126
      Location:150 → 220
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:332 → 605
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:92 → 117
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:92 → 161
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
      cl08302
      Location:19 → 81
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_040676719.2 → XP_040532653.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZSH0
      Conserved Domains (5) summary
      COG5126
      Location:149 → 219
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:331 → 604
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:91 → 116
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:91 → 160
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
      cl08302
      Location:18 → 80
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_046921951.1 → XP_046777907.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X6

      UniProtKB/TrEMBL
      A0A8V0ZSH0

    5. XM_046921952.1 → XP_046777908.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X7

      UniProtKB/TrEMBL
      A0A8V0ZPS8

    6. XM_040676720.2 → XP_040532654.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZPS8
      Conserved Domains (4) summary
      COG5126
      Location:122 → 192
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:304 → 577
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:64 → 89
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:64 → 133
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

    7. XM_040676721.2 → XP_040532655.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X5

      UniProtKB/TrEMBL
      A0A8V0ZPS8, A0A8V0ZSI4
      Conserved Domains (4) summary
      COG5126
      Location:117 → 187
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:299 → 572
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      cd15900
      Location:59 → 84
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:59 → 128
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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