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    ECT2 epithelial cell transforming 2 [ Gallus gallus (chicken) ]

    Gene ID: 424983, updated on 3-Dec-2024

    Summary

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    Symbol
    ECT2provided by CGNC
    Full Name
    epithelial cell transforming 2provided by CGNC
    Primary source
    CGNC:6968
    See related
    Ensembl:ENSGALG00010018517
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ECT2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (18928399..18955523, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (18716611..18743711, complement)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene neuroligin 1 Neighboring gene spermatogenesis associated 16 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene tumor necrosis factor superfamily member 10 Neighboring gene growth hormone secretagogue receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein ECT2
    Names
    epithelial cell transforming sequence 2 oncogene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      18928399..18955523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040706075.2 → XP_040562009.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    2. XM_015291706.4 → XP_015147192.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z6G2, E1BWT7
      Conserved Domains (4) summary
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456 → 640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    3. XM_015291707.4 → XP_015147193.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    4. XM_004943470.5 → XP_004943527.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_004943527.1

      UniProtKB/TrEMBL
      A0A8V0Z6G2, E1BWT7
      Related
      ENSGALP00010026735.1, ENSGALT00010044813.1
      Conserved Domains (4) summary
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456 → 640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    5. XM_040706074.2 → XP_040562008.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Related
      ENSGALP00010026731.1, ENSGALT00010044809.1
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    6. XM_004943469.5 → XP_004943526.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_004943526.1

      UniProtKB/TrEMBL
      A0A8V0Z6G2, E1BWT7
      Conserved Domains (4) summary
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456 → 640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    7. XM_046898490.1 → XP_046754446.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z6G2, E1BWT7

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      18716611..18743711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040679542.2 → XP_040535476.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    2. XM_040679539.2 → XP_040535473.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    3. XM_040679540.2 → XP_040535474.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    4. XM_040679536.2 → XP_040535470.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    5. XM_040679541.2 → XP_040535475.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:425 → 609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600 → 773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:239 → 318
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:145 → 220
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    6. XM_040679537.2 → XP_040535471.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z6G2
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:270 → 349
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:176 → 251
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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