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    HMBS hydroxymethylbilane synthase [ Gallus gallus (chicken) ]

    Gene ID: 419701, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HMBSprovided by CGNC
    Official Full Name
    hydroxymethylbilane synthaseprovided by CGNC
    Primary source
    CGNC:168
    See related
    Ensembl:ENSGALG00010024403
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HMBS in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (90871..101623, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (50687..61439, complement)

    Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene C2CD2 like Neighboring gene microRNA 1758 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene salt inducible kinase 2 Neighboring gene uncharacterized LOC121107537

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxymethylbilane synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-pyrromethane cofactor linkage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    porphobilinogen deaminase
    XP_004947973.1
    XP_015153561.1
    XP_024999057.1
    XP_024999058.1
    XP_040546529.1
    XP_040546530.1
    XP_040546531.1
    XP_040546532.1
    XP_040546533.1
    XP_046759737.1
    XP_046788365.1
    XP_417846.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      90871..101623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_417846.8 → XP_417846.2  porphobilinogen deaminase isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZS97
      Related
      ENSGALP00010036355.1, ENSGALT00010059537.1
      Conserved Domains (2) summary
      PRK00072
      Location:15 → 341
      hemC; porphobilinogen deaminase; Reviewed
      cd13645
      Location:17 → 296
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    2. XM_025143289.3 → XP_024999057.1  porphobilinogen deaminase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZS97
      Conserved Domains (1) summary
      cd13645
      Location:17 → 302
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    3. XM_015298075.4 → XP_015153561.1  porphobilinogen deaminase isoform X4

      UniProtKB/TrEMBL
      A0A8V1A1G1
      Conserved Domains (1) summary
      cd13645
      Location:1 → 259
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    4. XM_004947916.5 → XP_004947973.1  porphobilinogen deaminase isoform X5

      Conserved Domains (1) summary
      cd13645
      Location:28 → 238
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    5. XM_025143290.3 → XP_024999058.1  porphobilinogen deaminase isoform X3

      UniProtKB/TrEMBL
      A0A8V1A1G1
      Conserved Domains (1) summary
      cd13645
      Location:1 → 265
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    6. XM_046903781.1 → XP_046759737.1  porphobilinogen deaminase isoform X5

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      50687..61439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040690596.2 → XP_040546530.1  porphobilinogen deaminase isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZS97
      Conserved Domains (1) summary
      cd13645
      Location:17 → 296
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    2. XM_040690595.2 → XP_040546529.1  porphobilinogen deaminase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZS97
      Conserved Domains (1) summary
      cd13645
      Location:17 → 302
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    3. XM_040690598.2 → XP_040546532.1  porphobilinogen deaminase isoform X4

      UniProtKB/TrEMBL
      A0A8V1A1G1
      Conserved Domains (1) summary
      cd13645
      Location:1 → 259
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    4. XM_040690599.2 → XP_040546533.1  porphobilinogen deaminase isoform X5

      Conserved Domains (1) summary
      cd13645
      Location:28 → 238
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    5. XM_040690597.2 → XP_040546531.1  porphobilinogen deaminase isoform X3

      UniProtKB/TrEMBL
      A0A8V1A1G1
      Conserved Domains (1) summary
      cd13645
      Location:1 → 265
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    6. XM_046932409.1 → XP_046788365.1  porphobilinogen deaminase isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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