U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LITAF lipopolysaccharide induced TNF factor [ Gallus gallus (chicken) ]

    Gene ID: 374125, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    LITAFprovided by CGNC
    Full Name
    lipopolysaccharide induced TNF factorprovided by CGNC
    Primary source
    CGNC:2338
    See related
    Ensembl:ENSGALG00010021744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TNF-alpha
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LITAF in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (925629..945258)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (924136..943851)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 11 Neighboring gene stannin Neighboring gene uncharacterized LOC101751635 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds. Rohde F, et al. Front Immunol, 2018. PMID 29719531, Free PMC Article
    2. Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract. Gao X, et al. Biol Trace Elem Res, 2016 Sep. PMID 26899319
    3. Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF). Hong YH, et al. Dev Comp Immunol, 2006. PMID 16466659
    4. Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination. Das SC, et al. Reproduction, 2009 Mar. PMID 18539728
    5. The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. Sevimli A, et al. Vet Res Commun, 2008 Oct. PMID 18612836

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this paper provides characterization of chicken tumor necrosis factor-alpha
      Title: Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds.
    2. The results showed that Se deficiency induced high expression levels of PTGE, COX-2, TNF-alpha, and NF-kappaB in the gastrointestinal tract tissues.
      Title: Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract.
    3. The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
      Title: Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks.
    4. Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age.
      Title: Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium.
    5. IL1B and LITAF mRNAs are increased in the vagina during insemination. This response may lead to sperm degradation and elimination.
      Title: Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination.
    6. The expression of interleukin(IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in amyoidosis arthropathy in chickens was studied.
      Title: The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
    Names
    LPS-induced TNF-alpha factor homolog
    TNF-alpha factor
    lipid-induced TNF-alpha factor
    small integral membrane protein of lysosome/late endosome
    tissue necrosis factor-alpha
    tumor necrosis factor-alpha

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204267.2 → NP_989598.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

      See identical proteins and their annotated locations for NP_989598.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000257
      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
      Related
      ENSGALP00010031766.1, ENSGALT00010052860.1
      Conserved Domains (1) summary
      pfam10601
      Location:78 → 146
      zf-LITAF-like; LITAF-like zinc ribbon domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      925629..945258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046900549.1 → XP_046756505.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    2. XM_046900551.1 → XP_046756507.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
      Related
      ENSGALP00010031765.1, ENSGALT00010052859.1

    3. XM_015294124.4 → XP_015149610.2  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
      Conserved Domains (1) summary
      pfam10601
      Location:78 → 146
      zf-LITAF-like; LITAF-like zinc ribbon domain

    4. XM_040647304.2 → XP_040503238.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
      Conserved Domains (1) summary
      pfam10601
      Location:78 → 146
      zf-LITAF-like; LITAF-like zinc ribbon domain

    5. XM_015294121.4 → XP_015149607.2  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
      Conserved Domains (1) summary
      pfam10601
      Location:78 → 146
      zf-LITAF-like; LITAF-like zinc ribbon domain

    6. XM_046900550.1 → XP_046756506.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      924136..943851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927262.1 → XP_046783218.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    2. XM_046927263.1 → XP_046783219.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    3. XM_046927265.1 → XP_046783221.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    4. XM_046927261.1 → XP_046783217.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0

    5. XM_046927264.1 → XP_046783220.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8QGW7
      UniProtKB/TrEMBL
      A0A8V0ZLT0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QGW7.1 GenPept UniProtKB/Swiss-Prot:Q8QGW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials