NRP1 neuropilin 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NRP1provided by CGNC
Full Name: neuropilin 1provided by CGNC
Primary source: CGNC:5395
See related: Ensembl:ENSGALG00010005629
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: neuropilin-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (13814687..13923975)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (13843092..13950205)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knockdown of Npr1 and Slit2 in chick embryos caused motor neurons to migrate to the periphery
Title: Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.
NRP1-mediated Sema3A signals provide repulsive signals for MAP2-positive neurons to segregate tectal layers, which is important in order to coordinate laminar organization of the optic tectum.
Title: NRP1-mediated Sema3A signals coordinate laminar formation in the developing chick optic tectum.
This study demonstrates that the environmental toxin, sodium arsenite, induced angiogenesis by altering the expression of miRNAs and their cognate mRNA targets.
Title: MicroRNA-181b and microRNA-9 mediate arsenic-induced angiogenesis via NRP1.
post-transcriptional and local control of the availability of the Sema3A receptor neuropilin 1 at the growth cone surface
Title: Semaphorin and neuropilin co-expression in motoneurons sets axon sensitivity to environmental semaphorin sources during motor axon pathfinding.
Comparison of expression between mouse and chick embryos at early brain developmental stages.
Title: Expression of secreted semaphorins and their receptors in specific neuromeres, boundaries, and neuronal groups in the developing mouse and chick brain.
with the reduction of neuropilin-1 function, neural crest cells still form segmental migratory streams, suggesting that initial neural crest cell migration and invasion of the branchial arches are separable processes
Title: In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neuropilin-1

Names: A5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204782.1 → NP_990113.1 neuropilin-1 precursor

See identical proteins and their annotated locations for NP_990113.1

Status: PROVISIONAL

Source sequence(s)

D45416

UniProtKB/Swiss-Prot

P79795

Conserved Domains (4) summary

smart00137
Location:636 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:25 → 138

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:275 → 421

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:836 → 914

DUF3481; C-terminal domain of neuropilin glycoprotein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

13814687..13923975

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015281290.4 → XP_015136776.1 neuropilin-1 isoform X1

UniProtKB/TrEMBL

A0A8V0XQ20

Related

ENSGALP00010007997.1, ENSGALT00010013473.1

Conserved Domains (4) summary

smart00137
Location:643 → 801

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:25 → 138

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:275 → 421

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:843 → 921

DUF3481; C-terminal domain of neuropilin glycoprotein
XM_040675467.2 → XP_040531401.1 neuropilin-1 isoform X2

Conserved Domains (3) summary

smart00137
Location:636 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:25 → 138

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:275 → 421

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.