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    UBA3 ubiquitin like modifier activating enzyme 3 [ Gallus gallus (chicken) ]

    Gene ID: 426073, updated on 3-Dec-2024

    Summary

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    Symbol
    UBA3provided by CGNC
    Full Name
    ubiquitin like modifier activating enzyme 3provided by CGNC
    Primary source
    CGNC:52666
    See related
    Ensembl:ENSGALG00010020061
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    UBE1C
    Orthologs
    human mouse all
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    Genomic context

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    See UBA3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (15491969..15505758, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (15525583..15539382, complement)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene TATA element modulatory factor 1 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NEDD8 activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein neddylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD8-activating enzyme E1 catalytic subunit
    Names
    ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
    XP_003642074.3
    XP_004944741.2
    XP_015148736.1
    XP_015148737.1
    XP_015148738.1
    XP_025010525.1
    XP_040538397.1
    XP_040538398.1
    XP_046756184.1
    XP_046756185.1
    XP_046756186.1
    XP_046756187.1
    XP_046756188.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      15491969..15505758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046900228.1 → XP_046756184.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61

    2. XM_025154757.3 → XP_025010525.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61
      Related
      ENSGALP00010028585.1, ENSGALT00010048480.1
      Conserved Domains (2) summary
      cd01488
      Location:50 → 347
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:355 → 440
      E2_bind; E2 binding domain

    3. XM_046900231.1 → XP_046756187.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61

    4. XM_015293251.4 → XP_015148737.1  NEDD8-activating enzyme E1 catalytic subunit isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZBK2, A0A8V0ZJ11
      Related
      ENSGALP00010028588.1, ENSGALT00010048484.1
      Conserved Domains (3) summary
      cd01488
      Location:57 → 354
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:53 → 227
      ThiF; ThiF family
      pfam08825
      Location:362 → 447
      E2_bind; E2 binding domain

    5. XM_015293250.4 → XP_015148736.1  NEDD8-activating enzyme E1 catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZCG1, A0A8V0ZJ11
      Related
      ENSGALP00010028590.1, ENSGALT00010048486.1
      Conserved Domains (3) summary
      cd01488
      Location:71 → 368
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:67 → 241
      ThiF; ThiF family
      pfam08825
      Location:376 → 461
      E2_bind; E2 binding domain

    6. XM_046900229.1 → XP_046756185.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61

    7. XM_015293252.4 → XP_015148738.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61
      Conserved Domains (2) summary
      cd01488
      Location:50 → 347
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:355 → 440
      E2_bind; E2 binding domain

    8. XM_003642026.6 → XP_003642074.3  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61
      Conserved Domains (2) summary
      cd01488
      Location:50 → 347
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam08825
      Location:355 → 440
      E2_bind; E2 binding domain

    9. XM_046900230.1 → XP_046756186.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61

    10. XM_004944684.5 → XP_004944741.2  NEDD8-activating enzyme E1 catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZJ11
      Related
      ENSGALP00010028582.1, ENSGALT00010048473.1
      Conserved Domains (3) summary
      cd01488
      Location:65 → 362
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:61 → 235
      ThiF; ThiF family
      pfam08825
      Location:370 → 455
      E2_bind; E2 binding domain

    11. XM_046900232.1 → XP_046756188.1  NEDD8-activating enzyme E1 catalytic subunit isoform X4

      UniProtKB/TrEMBL
      A0A1D5PH51, A0A8V0ZJ11, E1BT61

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      15525583..15539382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040682464.2 → XP_040538398.1  NEDD8-activating enzyme E1 catalytic subunit isoform X6

      UniProtKB/TrEMBL
      A0A8V0ZJ11
      Conserved Domains (1) summary
      cd01488
      Location:57 → 356
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

    2. XM_040682463.2 → XP_040538397.1  NEDD8-activating enzyme E1 catalytic subunit isoform X5

      UniProtKB/TrEMBL
      A0A8V0ZJ11
      Conserved Domains (1) summary
      cd01488
      Location:71 → 370
      Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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