SIRT4 sirtuin 4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SIRT4provided by CGNC
Full Name: sirtuin 4provided by CGNC
Primary source: CGNC:5474
See related: Ensembl:ENSGALG00010021415
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (9389843..9398569, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (9389094..9399076, complement)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the expression levels of cSIRT1, cSIRT2, cSIRT4, cSIRT6, and cSIRT7 in the liver increased significantly with sexual maturity.
Title: Characteristics of expression and regulation of sirtuins in chicken (Gallus gallus).

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Names: NAD-dependent protein deacetylase sirtuin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9389843..9398569 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025155741.3 → XP_025011509.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3
XM_025155743.3 → XP_025011511.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4
XM_025155740.3 → XP_025011508.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2
XM_025155739.3 → XP_025011507.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1
XM_025155742.3 → XP_025011510.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4
XM_046901404.1 → XP_046757360.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37
XM_040648176.2 → XP_040504110.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040648175.2 → XP_040504109.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_025155747.3 → XP_025011515.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Related

ENSGALP00010030979.1, ENSGALT00010051911.1

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_025155746.3 → XP_025011514.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040648174.2 → XP_040504108.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_025155745.3 → XP_025011513.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_015275354.4 → XP_015130840.3 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

9389094..9399076 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040684999.2 → XP_040540933.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X8

Conserved Domains (1) summary

cl00195
Location:159 → 380

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685002.2 → XP_040540936.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X9

Conserved Domains (1) summary

cd01409
Location:159 → 420

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_040684998.2 → XP_040540932.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X7

Conserved Domains (1) summary

cl00195
Location:159 → 380

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040684997.2 → XP_040540931.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X6

Conserved Domains (1) summary

cl00195
Location:159 → 380

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685000.2 → XP_040540934.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X9

Conserved Domains (1) summary

cd01409
Location:159 → 420

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_046928496.1 → XP_046784452.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37
XM_040685008.2 → XP_040540942.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685007.2 → XP_040540941.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685003.2 → XP_040540937.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685006.2 → XP_040540940.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685005.2 → XP_040540939.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685004.2 → XP_040540938.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A8V0ZI37

Conserved Domains (1) summary

cl00195
Location:48 → 269

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_040685001.2 → XP_040540935.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X9

Conserved Domains (1) summary

cd01409
Location:159 → 420

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...