U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CACNA1D calcium voltage-gated channel subunit alpha1 D [ Gallus gallus (chicken) ]

    Gene ID: 395895, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    CACNA1Dprovided by CGNC
    Full Name
    calcium voltage-gated channel subunit alpha1 Dprovided by CGNC
    Primary source
    CGNC:49537
    See related
    Ensembl:ENSGALG00010027830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Summary
    This gene encodes a member of the voltage-dependent calcium channel protein subunit family. The cDNA for this gene was cloned from hair cells of the cochlea in the chicken inner ear. Study of the similar transmembrane protein in deficient mice reported impaired cardiac function and deafness, suggesting that the encoded protein is required for normal hearing and pacemaker activity in the heart. [provided by RefSeq, Aug 2012]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CACNA1D in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (7231874..7397607)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (7258746..7424552)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106674 Neighboring gene transketolase Neighboring gene uncharacterized LOC121106676 Neighboring gene decapping mRNA 1A Neighboring gene choline dehydrogenase Neighboring gene ARP8 actin-related protein 8 homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Development and regeneration of hair cells share common functional features. Levic S, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 18025474, Free PMC Article
    2. Hair cell-specific splicing of mRNA for the alpha1D subunit of voltage-gated Ca2+ channels in the chicken's cochlea. Kollmar R, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405709, Free PMC Article
    3. Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea. Kollmar R, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405708, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    voltage-dependent L-type calcium channel subunit alpha-1D
    Names
    CHCACHA1D
    L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D
    calcium channel, voltage-dependent, L type, alpha 1D subunit
    voltage-gated calcium channel subunit alpha Cav1.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205034.3 → NP_990365.1  voltage-dependent L-type calcium channel subunit alpha-1D

      See identical proteins and their annotated locations for NP_990365.1

      Status: REVIEWED

      Source sequence(s)
      JAENSK010000252
      UniProtKB/Swiss-Prot
      O73700, O73701, O73702, O73703, O73704
      UniProtKB/TrEMBL
      A0A8V1A5R9
      Related
      ENSGALP00010041246.1, ENSGALT00010067502.1
      Conserved Domains (4) summary
      pfam00520
      Location:138 → 412
      Ion_trans; Ion transport protein
      pfam08763
      Location:1577 → 1648
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1672 → 2187
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1575
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7231874..7397607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040646100.2 → XP_040502034.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1630 → 1660
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    2. XM_015292987.4 → XP_015148473.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

      UniProtKB/TrEMBL
      A0A8V1A5S5, A0A8V1ADG1
      Related
      ENSGALP00010041251.1, ENSGALT00010067508.1
      Conserved Domains (4) summary
      pfam00520
      Location:138 → 412
      Ion_trans; Ion transport protein
      pfam08763
      Location:1569 → 1640
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1664 → 2179
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1504 → 1567
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. XM_015292996.4 → XP_015148482.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

      UniProtKB/TrEMBL
      A0A1D5PY30, A0A8V1AHW6
      Related
      ENSGALP00010041258.1, ENSGALT00010067515.1
      Conserved Domains (4) summary
      pfam00520
      Location:1217 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1599
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1623 → 2129
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1463 → 1526
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. XM_040646099.2 → XP_040502033.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1630 → 1660
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    5. XM_040646102.2 → XP_040502036.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1630 → 1660
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    6. XM_040646104.2 → XP_040502038.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

      UniProtKB/TrEMBL
      A0A8V1AHW6
      Conserved Domains (1) summary
      smart01062
      Location:1617 → 1647
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    7. XM_040646105.2 → XP_040502039.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Related
      ENSGALP00010041245.1, ENSGALT00010067500.1
      Conserved Domains (1) summary
      smart01062
      Location:1602 → 1632
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    8. XM_040646107.2 → XP_040502041.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

      UniProtKB/TrEMBL
      A0A8V1AHW6
      Conserved Domains (1) summary
      smart01062
      Location:1589 → 1619
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    9. XM_046899820.1 → XP_046755776.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

      UniProtKB/TrEMBL
      A0A8V1A5S5

    10. XM_015292995.4 → XP_015148481.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

      UniProtKB/TrEMBL
      A0A8V1AHW6
      Conserved Domains (4) summary
      pfam00520
      Location:1217 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1599
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1623 → 2138
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1463 → 1526
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. XM_015293003.4 → XP_015148489.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (4) summary
      pfam00520
      Location:1217 → 1468
      Ion_trans; Ion transport protein
      pfam08763
      Location:1541 → 1612
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1636 → 2151
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1476 → 1539
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. XM_015293004.4 → XP_015148490.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

      UniProtKB/TrEMBL
      A0A8V1AAN9
      Conserved Domains (4) summary
      pfam00520
      Location:1217 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1599
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1623 → 2138
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1463 → 1526
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. XM_040646110.2 → XP_040502044.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

      UniProtKB/TrEMBL
      A0A8V1AAP3
      Conserved Domains (1) summary
      smart01062
      Location:1551 → 1581
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    14. XM_040646101.2 → XP_040502035.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1630 → 1660
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    15. XM_040646103.2 → XP_040502037.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1620 → 1650
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    16. XM_015292998.4 → XP_015148484.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

      UniProtKB/TrEMBL
      A0A8V1AHW6
      Conserved Domains (4) summary
      pfam00520
      Location:138 → 412
      Ion_trans; Ion transport protein
      pfam08763
      Location:1556 → 1627
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1651 → 2166
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1491 → 1554
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. XM_040646106.2 → XP_040502040.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Related
      ENSGALP00010041249.1, ENSGALT00010067506.1
      Conserved Domains (1) summary
      smart01062
      Location:1592 → 1622
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    18. XM_015293001.4 → XP_015148487.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

      UniProtKB/TrEMBL
      A0A8V1AAN9
      Conserved Domains (4) summary
      pfam00520
      Location:1217 → 1455
      Ion_trans; Ion transport protein
      pfam08763
      Location:1528 → 1599
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1623 → 2138
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1463 → 1526
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    19. XM_040646109.1 → XP_040502043.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1567 → 1597
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    20. XM_040646111.2 → XP_040502045.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

      UniProtKB/TrEMBL
      A0A8V1A5S5
      Conserved Domains (1) summary
      smart01062
      Location:1233 → 1263
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    21. XM_040646112.1 → XP_040502046.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

      Conserved Domains (1) summary
      smart01062
      Location:1191 → 1221
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7258746..7424552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926072.1 → XP_046782028.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

      UniProtKB/TrEMBL
      A0A8V1A5S5

    2. XM_046926076.1 → XP_046782032.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

      UniProtKB/TrEMBL
      A0A8V1A5S5, A0A8V1ADG1

    3. XM_046926087.1 → XP_046782043.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

      UniProtKB/TrEMBL
      A0A1D5PY30, A0A8V1AHW6

    4. XM_046926071.1 → XP_046782027.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

      UniProtKB/TrEMBL
      A0A8V1A5S5

    5. XM_046926074.1 → XP_046782030.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

      UniProtKB/TrEMBL
      A0A8V1A5S5

    6. XM_046926078.1 → XP_046782034.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

      UniProtKB/TrEMBL
      A0A8V1AHW6

    7. XM_046926080.1 → XP_046782036.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

      UniProtKB/TrEMBL
      A0A8V1A5S5

    8. XM_046926083.1 → XP_046782039.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

      UniProtKB/TrEMBL
      A0A8V1AHW6

    9. XM_046926075.1 → XP_046782031.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

      UniProtKB/TrEMBL
      A0A8V1A5S5

    10. XM_046926084.1 → XP_046782040.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

      UniProtKB/TrEMBL
      A0A8V1AHW6

    11. XM_046926081.1 → XP_046782037.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

      UniProtKB/TrEMBL
      A0A8V1A5S5

    12. XM_046926085.1 → XP_046782041.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

      UniProtKB/TrEMBL
      A0A8V1AAN9

    13. XM_046926089.1 → XP_046782045.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

      UniProtKB/TrEMBL
      A0A8V1AAP3

    14. XM_046926073.1 → XP_046782029.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

      UniProtKB/TrEMBL
      A0A8V1A5S5

    15. XM_046926077.1 → XP_046782033.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

      UniProtKB/TrEMBL
      A0A8V1A5S5

    16. XM_046926079.1 → XP_046782035.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

      UniProtKB/TrEMBL
      A0A8V1AHW6

    17. XM_046926082.1 → XP_046782038.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

      UniProtKB/TrEMBL
      A0A8V1A5S5

    18. XM_046926086.1 → XP_046782042.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

      UniProtKB/TrEMBL
      A0A8V1AAN9

    19. XM_046926088.1 → XP_046782044.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

      UniProtKB/TrEMBL
      A0A8V1A5S5

    20. XM_046926090.1 → XP_046782046.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

      UniProtKB/TrEMBL
      A0A8V1A5S5

    21. XM_046926091.1 → XP_046782047.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73700.1 GenPept UniProtKB/Swiss-Prot:O73700

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.