CATH1 cathelicidin 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CATH1provided by CGNC
Official Full Name: cathelicidin 1provided by CGNC
Primary source: CGNC:49912
See related: Ensembl:ENSGALG00010025943
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CATH-1; CATH-3; CATHL1
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (4015652..4017138, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (4018076..4019562, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo.
Title: The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo.
These current observations suggest that CATH1, -2 and -3 in the vagina are upregulated by IL1B, and CATH3 in the uterus is also upregulated by IL6.
Title: Modulatory roles of proinflammatory cytokines on the expression of cathelicidins in the lower regions of the oviduct of laying hens.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cathelicidin-1

Names: cathelicidin antimicrobial peptide; cathelicidin-3; fowlicidin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001605.3 → NP_001001605.1 cathelicidin-1 precursor

See identical proteins and their annotated locations for NP_001001605.1

Status: PROVISIONAL

Source sequence(s)

BX936022

UniProtKB/Swiss-Prot

Q2IAM1, Q6QLQ5

UniProtKB/TrEMBL

A0A165FX80, C4PFJ7

Related

ENSGALP00010039049.1, ENSGALT00010063250.1

Conserved Domains (1) summary

pfam00666
Location:22 → 87

Cathelicidins; Cathelicidin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4015652..4017138 complement

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GenBank, FASTA, Sequence Viewer (Graphics)