FN1 fibronectin 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FN1provided by CGNC
Official Full Name: fibronectin 1provided by CGNC
Primary source: CGNC:2613
See related: Ensembl:ENSGALG00010011984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: FN
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (4440758..4490944, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (4382075..4432210, complement)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
Title: Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
Title: Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues.
cell rearrangements guided by a fibronectin matrix have a role in somitogenesis
Title: Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis.
We provide a hypothesis whereby a combination of activated surface integrin levels and the degree to which those receptors are clustered determines NCC motility on fibronectin.
Title: Neural crest motility on fibronectin is regulated by integrin activation.
fibronectin is produced by radial glia and is aligned along their surfaces before and during migration
Title: Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables proteoglycan binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-substrate junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibronectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198712.2 → NP_001185641.1 fibronectin precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000235

UniProtKB/Swiss-Prot

F1NJT3, P11722, Q90921

UniProtKB/TrEMBL

A0A8V0YC34

Related

ENSGALP00010016500.1, ENSGALT00010028696.1

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:2000 → 2080

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2302 → 2341

fn1; Fibronectin type I domain

pfam00041
Location:1544 → 1625

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4440758..4490944 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046943492.1 → XP_046799448.1 fibronectin isoform X6

UniProtKB/TrEMBL

A0A8V0YC34

Related

ENSGALP00010016522.1, ENSGALT00010028720.1
XM_046943491.1 → XP_046799447.1 fibronectin isoform X3

UniProtKB/TrEMBL

A0A8V0YC34
XM_015289128.4 → XP_015144614.1 fibronectin isoform X1

UniProtKB/TrEMBL

A0A8V0YC34

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:2000 → 2080

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2302 → 2341

fn1; Fibronectin type I domain

pfam00041
Location:1544 → 1625

fn3; Fibronectin type III domain
XM_015289133.4 → XP_015144619.1 fibronectin isoform X8

UniProtKB/TrEMBL

A0A8V0YC34

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1819 → 1899

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2121 → 2160

fn1; Fibronectin type I domain

pfam00041
Location:1453 → 1534

fn3; Fibronectin type III domain
XM_015289132.4 → XP_015144618.1 fibronectin isoform X5

UniProtKB/TrEMBL

A0A8V0YC34, A0A8V0YDD6

Related

ENSGALP00010016514.1, ENSGALT00010028712.1

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1909 → 1989

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2211 → 2250

fn1; Fibronectin type I domain

pfam00041
Location:1453 → 1534

fn3; Fibronectin type III domain
XM_046943493.1 → XP_046799449.1 fibronectin isoform X7

UniProtKB/TrEMBL

A0A8V0YC34
XM_015289131.4 → XP_015144617.1 fibronectin isoform X4

UniProtKB/TrEMBL

A0A8V0YC34, A0A8V0YFJ8

Related

ENSGALP00010016505.1, ENSGALT00010028702.1

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1910 → 1990

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2212 → 2251

fn1; Fibronectin type I domain

pfam00041
Location:1544 → 1625

fn3; Fibronectin type III domain
XM_015289129.4 → XP_015144615.1 fibronectin isoform X2

UniProtKB/TrEMBL

A0A8V0YC34

Conserved Domains (6) summary

smart00059
Location:418 → 466

FN2; Fibronectin type 2 domain

smart00058
Location:188 → 232

FN1; Fibronectin type 1 domain

cd00061
Location:53 → 91

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:2000 → 2080

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:2258 → 2297

fn1; Fibronectin type I domain

pfam00041
Location:1544 → 1625

fn3; Fibronectin type III domain