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    LIG4 DNA ligase 4 [ Gallus gallus (chicken) ]

    Gene ID: 418764, updated on 7-Dec-2024

    Summary

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    Symbol
    LIG4provided by CGNC
    Full Name
    DNA ligase 4provided by CGNC
    Primary source
    CGNC:12647
    See related
    Ensembl:ENSGALG00010014974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See LIG4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (140238778..140242673)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (140222010..140225902)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor superfamily member 13b Neighboring gene abhydrolase domain containing 13 Neighboring gene SPARC Neighboring gene family with sequence similarity 155 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair. Adachi N, et al. Proc Natl Acad Sci U S A, 2001 Oct 9. PMID 11593023, Free PMC Article
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA ligation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 4
    Names
    DNA ligase (ATP) 4
    DNA ligase IV
    ligase IV, DNA, ATP-dependent
    polydeoxyribonucleotide synthase [ATP] 4
    NP_001025987.1
    XP_015129663.2
    XP_046764071.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030816.1 → NP_001025987.1  DNA ligase 4

      See identical proteins and their annotated locations for NP_001025987.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ720061
      UniProtKB/Swiss-Prot
      Q5ZKM3, Q90YB1
      Related
      ENSGALP00010020904.1, ENSGALT00010036012.1
      Conserved Domains (7) summary
      cd07968
      Location:464 → 601
      OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
      cd07903
      Location:240 → 461
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      cd00027
      Location:846 → 900
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      TIGR00574
      Location:86 → 607
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam00533
      Location:664 → 735
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam04675
      Location:20 → 208
      DNA_ligase_A_N; DNA ligase N terminus
      pfam11411
      Location:755 → 788
      DNA_ligase_IV; DNA ligase IV

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      140238778..140242673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015274177.4 → XP_015129663.2  DNA ligase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YS61
      Related
      ENSGALP00010020911.1, ENSGALT00010036019.1
      Conserved Domains (3) summary
      TIGR00574
      Location:86 → 607
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      cd17717
      Location:814 → 901
      BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
      cd17722
      Location:663 → 750
      BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      140222010..140225902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908115.1 → XP_046764071.1  DNA ligase 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90YB1.2 GenPept UniProtKB/Swiss-Prot:Q90YB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.