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    ITCH itchy E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

    Gene ID: 419145, updated on 3-Dec-2024

    Summary

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    Symbol
    ITCHprovided by CGNC
    Full Name
    itchy E3 ubiquitin protein ligaseprovided by CGNC
    Primary source
    CGNC:1384
    See related
    Ensembl:ENSGALG00010024723
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ITCH in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (1764094..1831397, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (1558313..1631200, complement)

    Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene dynein light chain roadblock-type 1 Neighboring gene protein MANBAL-like Neighboring gene mannosidase, beta A, lysosomal-like 13 Neighboring gene U1 spliceosomal RNA Neighboring gene adenosylhomocysteinase Neighboring gene agouti signaling protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein K29-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Itchy homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1764094..1831397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040650890.2 → XP_040506824.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Related
      ENSGALP00010037118.1, ENSGALT00010060359.1
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    2. XM_040650891.2 → XP_040506825.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZZG2
      Related
      ENSGALP00010037108.1, ENSGALT00010060349.1
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:303 → 335
      WW; Domain with 2 conserved Trp (W) residues
      COG5021
      Location:335 → 713
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1558313..1631200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040688410.2 → XP_040544344.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    2. XM_040688404.2 → XP_040544338.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    3. XM_040688417.2 → XP_040544351.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    4. XM_040688414.2 → XP_040544348.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    5. XM_040688416.2 → XP_040544350.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    6. XM_040688413.2 → XP_040544347.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    7. XM_040688412.2 → XP_040544346.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    8. XM_040688405.2 → XP_040544339.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    9. XM_046931083.1 → XP_046787039.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3

    10. XM_046931082.1 → XP_046787038.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3

    11. XM_040688415.2 → XP_040544349.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    12. XM_040688409.2 → XP_040544343.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    13. XM_040688406.2 → XP_040544340.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    14. XM_040688403.2 → XP_040544337.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    15. XM_040688402.2 → XP_040544336.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZZH3
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      COG5021
      Location:335 → 878
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:304 → 333
      WW; WW domain

    16. XM_040688418.2 → XP_040544352.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZZG2
      Conserved Domains (3) summary
      cd04021
      Location:17 → 139
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:303 → 335
      WW; Domain with 2 conserved Trp (W) residues
      COG5021
      Location:335 → 713
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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