U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    APLP2 amyloid beta precursor like protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 419727, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    APLP2provided by CGNC
    Official Full Name
    amyloid beta precursor like protein 2provided by CGNC
    Primary source
    CGNC:51073
    See related
    Ensembl:ENSGALG00010023571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Annotation information
    Note: On NCBI's Build 1.1, this GeneID was assigned to APLP2. Before Build 2.1, a chimeric/readthrough mRNA that encoded part of the neighboring NFRKB gene as well as part of APLP2 was associated with this GeneID, which resulted in the generation of NM_001006317.1. In October 2010, the nomenclature for GeneID 419727 and the sequence data for NM_001006317 were updated to correctly reflect the APLP2 gene. [13 Feb 2013]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See APLP2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (1495546..1536732, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (1455221..1496373, complement)

    Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107516 Neighboring gene BARX homeobox 2 Neighboring gene transmembrane protein 45B Neighboring gene transmembrane protein 45 like Neighboring gene PR domain 10 Neighboring gene uncharacterized LOC124417384 Neighboring gene nuclear factor related to kappaB binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Non-coding RNAs revealed during identification of genes involved in chicken immune responses. Ahanda ML, et al. Immunogenetics, 2009 Jan. PMID 19009289
    2. ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Savolainen P, et al. Cytogenet Genome Res, 2005. PMID 16093725
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    amyloid beta precursor like protein 2
    Names
    amyloid beta (A4) precursor-like protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006317.4 → NP_001006317.2  amyloid beta precursor like protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000341
      UniProtKB/TrEMBL
      F1P0A7
      Related
      ENSGALP00010034882.1, ENSGALT00010057403.1
      Conserved Domains (6) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      pfam00014
      Location:299 → 351
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:41 → 141
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:699 → 749
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:143 → 198
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:355 → 532
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1495546..1536732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040652052.2 → XP_040507986.1  amyloid beta precursor like protein 2 isoform X7

      Conserved Domains (2) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:332 → 512
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

    2. XM_040652051.2 → XP_040507985.1  amyloid beta precursor like protein 2 isoform X6

      Conserved Domains (2) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:332 → 512
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

    3. XM_040652050.2 → XP_040507984.1  amyloid beta precursor like protein 2 isoform X5

      Conserved Domains (2) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:332 → 512
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

    4. XM_040652049.2 → XP_040507983.1  amyloid beta precursor like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZWX1
      Related
      ENSGALP00010034871.1, ENSGALT00010057377.1
      Conserved Domains (2) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:332 → 512
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

    5. XM_040652048.2 → XP_040507982.1  amyloid beta precursor like protein 2 isoform X3

      Conserved Domains (3) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:388 → 568
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00109
      Location:298 → 351
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    6. XM_040652047.2 → XP_040507981.1  amyloid beta precursor like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A108
      Related
      ENSGALP00010034874.1, ENSGALT00010057386.1
      Conserved Domains (3) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:388 → 568
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00109
      Location:298 → 351
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    7. XM_040652046.2 → XP_040507980.1  amyloid beta precursor like protein 2 isoform X1

      Conserved Domains (3) summary
      smart00006
      Location:34 → 198
      A4_EXTRA; amyloid A4
      COG4942
      Location:388 → 568
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00109
      Location:298 → 351
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1455221..1496373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932338.1 → XP_046788294.1  amyloid beta precursor like protein 2 isoform X7

    2. XM_046932337.1 → XP_046788293.1  amyloid beta precursor like protein 2 isoform X6

    3. XM_046932336.1 → XP_046788292.1  amyloid beta precursor like protein 2 isoform X5

    4. XM_046932335.1 → XP_046788291.1  amyloid beta precursor like protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZWX1

    5. XM_046932334.1 → XP_046788290.1  amyloid beta precursor like protein 2 isoform X3

    6. XM_046932333.1 → XP_046788289.1  amyloid beta precursor like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A108

    7. XM_046932332.1 → XP_046788288.1  amyloid beta precursor like protein 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.