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    PRKCA protein kinase C alpha [ Gallus gallus (chicken) ]

    Gene ID: 417430, updated on 3-Dec-2024

    Summary

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    Symbol
    PRKCAprovided by CGNC
    Full Name
    protein kinase C alphaprovided by CGNC
    Primary source
    CGNC:50506
    See related
    Ensembl:ENSGALG00010029209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCA in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (7945750..8084827, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (7540629..7679608, complement)

    Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107130 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene centrosomal protein 112 Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC107052245 Neighboring gene axin 2 Neighboring gene regulator of G-protein signaling 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase. Lee YA, et al. Mol Cells, 2007 Aug 31. PMID 17846494
    2. Reduced PKCalpha expression in pulmonary arterioles of broiler chickens is associated with early feed restriction. Pan JQ, et al. Res Vet Sci, 2008 Jun. PMID 17707446
    3. Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Guo D, et al. Mol Cell Neurosci, 2012 May. PMID 22521536, Free PMC Article
    4. Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. Tunsophon S, et al. Steroids, 2010 Apr. PMID 20079367
    5. Role of interleukin-6 in the control of DNA synthesis of hepatocytes: involvement of PKC, p44/42 MAPKs, and PPARdelta. Suh HN, et al. Cell Physiol Biochem, 2008. PMID 19088449

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKCalpha directly phosphorylates integrin-linked kinase on threonine-173 and -181 in vitro. Dominant negative PKCalpha disrupts RGC axon pathfinding at the optic chiasm.
      Title: Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.
    2. PKCalpha and PKCbeta are both involved in steroid-stimulated phosphate uptake.
      Title: Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake.
    3. IL-6 stimulates the proliferation of primary cultured chicken hepatocytes through PKC, p44/42 MAPKs, and PPARdelta pathways.
      Title: Role of interleukin-6 in the control of DNA synthesis of hepatocytes: involvement of PKC, p44/42 MAPKs, and PPARdelta.
    4. IL-6 stimulates the 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca(2+)/PKC and EGF receptor in primary cultured chicken hepatocytes.
      Title: Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes.
    5. Short time exposure to hypoxia increases DNA synthesis in primary cultured chicken hepatocytes through cooperation of Ca2+/PKC, p38 MAPK, p44/42 MAPKs, and PI3K/Akt pathways.
      Title: A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: Correlation between Ca(2+)/PKC/MAPKs and PI3K/Akt/mTOR.
    6. Early time feed restriction inhibits pulmonary vascular remodeling in broilers, which may be partly attributed to reduced PKCalpha expression in pulmonary arterioles.
      Title: Reduced PKCalpha expression in pulmonary arterioles of broiler chickens is associated with early feed restriction.
    7. p38 MAP kinase activities are required for chondrocyte redifferentiation in a model system of dedifferentiated chondrocytes
      Title: Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase.
    8. PKC and p38 MAP kinase activities are required for chondrocyte redifferentiation in a model system of dedifferentiated chondrocytes.
      Title: Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase.
    9. binding of annexin V to active PKCalpha stimulates apoptotic events in growth plate chondrocytes and binding of annexin V to beta5 integrin controls these interactions and ultimately apoptosis
      Title: Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C alpha type
    NP_001012822.1
    XP_004946286.1
    XP_024997373.1
    XP_040505434.1
    XP_040505435.1
    XP_040505436.1
    XP_040505437.1
    XP_046757994.1
    XP_046757995.1
    XP_046757996.1
    XP_046757998.1
    XP_046785380.1
    XP_046785381.1
    XP_046785382.1
    XP_046785383.1
    XP_046785384.1
    XP_046785385.1
    XP_046785386.1
    XP_046785387.1
    XP_046785388.1
    XP_046785389.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012804.2 → NP_001012822.1  protein kinase C alpha type

      See identical proteins and their annotated locations for NP_001012822.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000317
      UniProtKB/TrEMBL
      A0A8V1ABC9, Q5F3X1
      Related
      ENSGALP00010043281.1, ENSGALT00010070590.1
      Conserved Domains (4) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:341 → 599
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05615
      Location:330 → 670
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      pfam00130
      Location:37 → 89
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      7945750..8084827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040649503.2 → XP_040505437.1  protein kinase C alpha type isoform X6

      Conserved Domains (3) summary
      cd04026
      Location:30 → 160
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05615
      Location:209 → 549
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      cl00040
      Location:1 → 26
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    2. XM_025141605.3 → XP_024997373.1  protein kinase C alpha type isoform X6

      Conserved Domains (3) summary
      cd04026
      Location:30 → 160
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05615
      Location:209 → 549
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      cl00040
      Location:1 → 26
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_046902039.1 → XP_046757995.1  protein kinase C alpha type isoform X4

      UniProtKB/TrEMBL
      A0A8V1ABC9

    4. XM_046902038.1 → XP_046757994.1  protein kinase C alpha type isoform X4

      UniProtKB/TrEMBL
      A0A8V1ABC9

    5. XM_046902042.1 → XP_046757998.1  protein kinase C alpha type isoform X6

    6. XM_046902040.1 → XP_046757996.1  protein kinase C alpha type isoform X6

    7. XM_004946229.5 → XP_004946286.1  protein kinase C alpha type isoform X3

      UniProtKB/TrEMBL
      A0A8V1ABC9, R4GHL2
      Related
      ENSGALP00010043283.1, ENSGALT00010070592.1
      Conserved Domains (4) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:349 → 607
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05615
      Location:338 → 678
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      pfam00130
      Location:37 → 89
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    8. XM_040649501.2 → XP_040505435.1  protein kinase C alpha type isoform X2

      UniProtKB/TrEMBL
      A0A8V1ABC9, A0A8V1AMK5
      Related
      ENSGALP00010043282.1, ENSGALT00010070591.1
      Conserved Domains (3) summary
      cd04026
      Location:236 → 366
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00109
      Location:179 → 228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd05615
      Location:407 → 747
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

    9. XM_040649500.2 → XP_040505434.1  protein kinase C alpha type isoform X1

      UniProtKB/TrEMBL
      A0A8V1ABC9
      Conserved Domains (3) summary
      cd04026
      Location:236 → 366
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00109
      Location:179 → 228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd05615
      Location:415 → 755
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

    10. XM_040649502.2 → XP_040505436.1  protein kinase C alpha type isoform X5

      Conserved Domains (3) summary
      cd04026
      Location:236 → 366
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00109
      Location:179 → 228
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl21453
      Location:429 → 597
      PKc_like; Protein Kinases, catalytic domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      7540629..7679608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046929432.1 → XP_046785388.1  protein kinase C alpha type isoform X6

    2. XM_046929430.1 → XP_046785386.1  protein kinase C alpha type isoform X6

    3. XM_046929428.1 → XP_046785384.1  protein kinase C alpha type isoform X4

      UniProtKB/TrEMBL
      A0A8V1ABC9

    4. XM_046929427.1 → XP_046785383.1  protein kinase C alpha type isoform X4

      UniProtKB/TrEMBL
      A0A8V1ABC9

    5. XM_046929433.1 → XP_046785389.1  protein kinase C alpha type isoform X6

    6. XM_046929431.1 → XP_046785387.1  protein kinase C alpha type isoform X6

    7. XM_046929426.1 → XP_046785382.1  protein kinase C alpha type isoform X3

      UniProtKB/TrEMBL
      A0A8V1ABC9, R4GHL2

    8. XM_046929425.1 → XP_046785381.1  protein kinase C alpha type isoform X2

      UniProtKB/TrEMBL
      A0A8V1ABC9

    9. XM_046929424.1 → XP_046785380.1  protein kinase C alpha type isoform X1

      UniProtKB/TrEMBL
      A0A8V1ABC9

    10. XM_046929429.1 → XP_046785385.1  protein kinase C alpha type isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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