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    RAPGEF2 Rap guanine nucleotide exchange factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 422418, updated on 3-Dec-2024

    Summary

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    Symbol
    RAPGEF2provided by CGNC
    Full Name
    Rap guanine nucleotide exchange factor 2provided by CGNC
    Primary source
    CGNC:14130
    See related
    Ensembl:ENSGALG00010009026
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RAPGEF2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (21503578..21678001)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (21579358..21752729)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene folliculin interacting protein 2 Neighboring gene uncharacterized LOC121110656 Neighboring gene C4orf45 homolog Neighboring gene uncharacterized LOC121110657 Neighboring gene NADH-ubiquinone oxidoreductase chain 2-like Neighboring gene uncharacterized LOC121110658 Neighboring gene uncharacterized LOC124417939

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 2
    Names
    Rap guanine nucleotide exchange factor (GEF) 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      21503578..21678001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046940691.1 → XP_046796647.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Y8E7

    2. XM_046940692.1 → XP_046796648.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Y8E7

    3. XM_004940909.5 → XP_004940966.3  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_040699701.2 → XP_040555635.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_040699705.2 → XP_040555639.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_040699702.2 → XP_040555636.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y1T1, A0A8V0Y1V1
      Related
      ENSGALP00010012273.1, ENSGALT00010021544.1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_040699704.2 → XP_040555638.1  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_040699708.2 → XP_040555642.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_420387.8 → XP_420387.6  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y1T5, A0A8V0Y1V1
      Related
      ENSGALP00010012278.1, ENSGALT00010021554.1
      Conserved Domains (7) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:559 → 683
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_040699707.2 → XP_040555641.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:274 → 389
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:405 → 518
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:851 → 1076
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:522 → 602
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:542 → 666
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:746 → 828
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_040699711.2 → XP_040555645.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:247 → 362
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:378 → 491
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:824 → 1049
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:495 → 575
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:515 → 639
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:719 → 801
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_040699703.2 → XP_040555637.1  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y455
      Related
      ENSGALP00010012263.1, ENSGALT00010021524.1
      Conserved Domains (7) summary
      smart00100
      Location:286 → 401
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:417 → 530
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:26 → 132
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:863 → 1088
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:534 → 614
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:554 → 678
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:758 → 840
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_040699712.2 → XP_040555646.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8V0XZW6
      Related
      ENSGALP00010012246.1, ENSGALT00010021496.1
      Conserved Domains (6) summary
      smart00100
      Location:134 → 249
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:265 → 378
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:711 → 936
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:382 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:402 → 526
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:606 → 688
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    14. XM_004940910.5 → XP_004940967.2  rap guanine nucleotide exchange factor 2 isoform X13

      UniProtKB/TrEMBL
      A0A8V0XZW6
      Related
      ENSGALP00010012254.1, ENSGALT00010021508.1
      Conserved Domains (6) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:404 → 528
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      21579358..21752729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046916683.1 → XP_046772639.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Y8E7

    2. XM_046916682.1 → XP_046772638.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0Y8E7

    3. XM_040670706.2 → XP_040526640.1  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_040670708.2 → XP_040526642.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_040670712.2 → XP_040526646.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_040670709.2 → XP_040526643.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_040670711.2 → XP_040526645.1  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_040670715.2 → XP_040526649.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:565 → 689
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_040670707.2 → XP_040526641.1  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:559 → 683
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_040670714.2 → XP_040526648.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:274 → 389
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:405 → 518
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:851 → 1076
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:522 → 602
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:542 → 666
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:746 → 828
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_040670717.2 → XP_040526651.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0Y1V1
      Conserved Domains (7) summary
      smart00100
      Location:247 → 362
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:378 → 491
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:824 → 1049
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:495 → 575
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:515 → 639
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:719 → 801
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_040670710.2 → XP_040526644.1  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0Y455
      Conserved Domains (7) summary
      smart00100
      Location:286 → 401
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:417 → 530
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:26 → 132
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:863 → 1088
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:534 → 614
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:554 → 678
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:758 → 840
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_040670719.2 → XP_040526653.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8V0XZW6
      Conserved Domains (6) summary
      smart00100
      Location:134 → 249
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:265 → 378
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:711 → 936
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:382 → 462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:402 → 526
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:606 → 688
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    14. XM_040670718.2 → XP_040526652.1  rap guanine nucleotide exchange factor 2 isoform X13

      UniProtKB/TrEMBL
      A0A8V0XZW6
      Conserved Domains (6) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02037
      Location:404 → 528
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    Nucleotide Protein Strain
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