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    MAP2K5 mitogen-activated protein kinase kinase 5 [ Gallus gallus (chicken) ]

    Gene ID: 415557, updated on 3-Dec-2024

    Summary

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    Symbol
    MAP2K5provided by CGNC
    Full Name
    mitogen-activated protein kinase kinase 5provided by CGNC
    Primary source
    CGNC:50016
    See related
    Ensembl:ENSGALG00010017039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See MAP2K5 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (18972768..19084709)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (18837492..18949511)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene alpha- and gamma-adaptin binding protein Neighboring gene IQ motif containing H Neighboring gene chromosome 15 open reading frame 61 Neighboring gene uncharacterized LOC107054238 Neighboring gene microRNA 1642 Neighboring gene SKI family transcriptional corepressor 1 Neighboring gene protein inhibitor of activated STAT 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function. Abdrakhmanov I, et al. Genome Res, 2000 Dec. PMID 11116100, Free PMC Article
    2. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 5
    NP_001269277.1
    XP_015147584.2
    XP_015147585.2
    XP_015147587.2
    XP_046755026.1
    XP_046780874.1
    XP_046780875.1
    XP_046780876.1
    XP_046780877.1
    XP_046780878.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282348.2 → NP_001269277.1  dual specificity mitogen-activated protein kinase kinase 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000246
      UniProtKB/TrEMBL
      A0A8V0YZ74, A0A8V0Z106
      Related
      ENSGALP00010024098.1, ENSGALT00010041172.1
      Conserved Domains (3) summary
      cd06395
      Location:18 → 108
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:165 → 443
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
      smart00220
      Location:171 → 420
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      18972768..19084709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015292099.4 → XP_015147585.2  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZ86, A0A8V0YZJ8
      Related
      ENSGALP00010024085.1, ENSGALT00010041157.1
      Conserved Domains (2) summary
      cd06395
      Location:18 → 108
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:165 → 407
      PKc_like; Protein Kinases, catalytic domain

    2. XM_015292098.4 → XP_015147584.2  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z106, A0A8V0Z6H1
      Related
      ENSGALP00010024092.1, ENSGALT00010041165.1
      Conserved Domains (2) summary
      cd06395
      Location:18 → 108
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:165 → 433
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    3. XM_015292101.4 → XP_015147587.2  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YSU5
      Conserved Domains (2) summary
      cd06395
      Location:18 → 108
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:165 → 359
      PKc_like; Protein Kinases, catalytic domain

    4. XM_046899070.1 → XP_046755026.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

      UniProtKB/TrEMBL
      Q5ZHL2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      18837492..18949511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924919.1 → XP_046780875.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZ86, A0A8V0YZJ8

    2. XM_046924918.1 → XP_046780874.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z106, A0A8V0Z6H1

    3. XM_046924920.1 → XP_046780876.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YZ86

    4. XM_046924921.1 → XP_046780877.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YSU5

    5. XM_046924922.1 → XP_046780878.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

      UniProtKB/TrEMBL
      Q5ZHL2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001079716.1: Suppressed sequence

      Description
      NM_001079716.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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