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    CDON cell adhesion associated, oncogene regulated [ Gallus gallus (chicken) ]

    Gene ID: 419710, updated on 3-Dec-2024

    Summary

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    Symbol
    CDONprovided by CGNC
    Full Name
    cell adhesion associated, oncogene regulatedprovided by CGNC
    Primary source
    CGNC:51066
    See related
    Ensembl:ENSGALG00010023809
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See CDON in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 24 NC_052555.1 (379852..420398, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 24 NC_052596.1 (339651..380671, complement)

    Chromosome 24 - NC_052555.1Genomic Context describing neighboring genes Neighboring gene HYLS1, centriolar and ciliogenesis associated Neighboring gene hemicentin-2-like Neighboring gene pseudouridylate synthase 3 Neighboring gene checkpoint kinase 1 Neighboring gene STT3A, catalytic subunit of the oligosaccharyltransferase complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development. Delloye-Bourgeois C, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25193697
    2. Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Cardozo MJ, et al. Nat Commun, 2014 Jul 8. PMID 25001599, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog protein, thereby limiting its dispersion.
      Title: Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle.
    2. SHH promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development.
      Title: Sonic Hedgehog promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell adhesion molecule-related/down-regulated by oncogenes; LOW QUALITY PROTEIN: cell adhesion molecule-related/down-regulated by oncogenes
    Names
    Cdon homolog
    surface glycoprotein, Ig superfamily member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      379852..420398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046903791.1 → XP_046759747.1  LOW QUALITY PROTEIN: cell adhesion molecule-related/down-regulated by oncogenes

      UniProtKB/TrEMBL
      A0A8V0ZUE7
      Related
      ENSGALP00010035213.1, ENSGALT00010058035.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052596.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      339651..380671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040690429.2 → XP_040546363.1  cell adhesion molecule-related/down-regulated by oncogenes

      UniProtKB/TrEMBL
      A0A8V0ZUE7
      Conserved Domains (4) summary
      smart00408
      Location:320 → 381
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:127 → 193
      IG; Immunoglobulin
      cd00063
      Location:591 → 678
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:314 → 318
      Ig; Ig strand A' [structural motif]

    2. XM_040690428.2 → XP_040546362.1  cell adhesion molecule-related/down-regulated by oncogenes

      UniProtKB/TrEMBL
      A0A8V0ZUE7
      Conserved Domains (4) summary
      smart00408
      Location:320 → 381
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:127 → 193
      IG; Immunoglobulin
      cd00063
      Location:591 → 678
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:314 → 318
      Ig; Ig strand A' [structural motif]

    3. XM_040690427.2 → XP_040546361.1  cell adhesion molecule-related/down-regulated by oncogenes

      UniProtKB/TrEMBL
      A0A8V0ZUE7
      Conserved Domains (4) summary
      smart00408
      Location:320 → 381
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:127 → 193
      IG; Immunoglobulin
      cd00063
      Location:591 → 678
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:314 → 318
      Ig; Ig strand A' [structural motif]

    4. XM_046932419.1 → XP_046788375.1  cell adhesion molecule-related/down-regulated by oncogenes

      UniProtKB/TrEMBL
      A0A8V0ZUE7
    Nucleotide Protein Strain
    Heading Accession and Version

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